| Identification | Back Directory | [Name]
1H-PYRAZOL-4-YLAMINE | [CAS]
28466-26-4 | [Synonyms]
AKOS PAO-0001
4-AMINOPYRAZOLE
1H-Pyrazol-4-amine
4-Aminopyrazole 95%
4-AMINO-1H-PYRAZOLE
1H-Pyrazole-4-amine
H-PYRAZOL-4-YLAMINE
1H-PYRAZOL-4-YLAMINE | [EINECS(EC#)]
625-292-2 | [Molecular Formula]
C3H5N3 | [MDL Number]
MFCD01693729 | [MOL File]
28466-26-4.mol | [Molecular Weight]
83.0919 |
| Chemical Properties | Back Directory | [Melting point ]
75-77°C | [Boiling point ]
142.17°C (rough estimate) | [density ]
1.0248 (rough estimate) | [refractive index ]
1.5060 (estimate) | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [form ]
powder to crystal | [pka]
17.70±0.50(Predicted) | [color ]
White to Brown to Dark purple | [Sensitive ]
Hygroscopic | [InChI]
InChI=1S/C3H5N3/c4-3-1-5-6-2-3/h1-2H,4H2,(H,5,6) | [InChIKey]
AXINVSXSGNSVLV-UHFFFAOYSA-N | [SMILES]
N1C=C(N)C=N1 | [CAS DataBase Reference]
28466-26-4 | [NIST Chemistry Reference]
4-NH2-pyrazole(28466-26-4) |
| Hazard Information | Back Directory | [Uses]
4-Aminopyrazole, is a versatile building block for the preparation of pharmaceutical and biologically active compounds. 4-Amino-1H-pyrazole, has also shown to have anticonvulsant activity, and thus can be used in the treatment of epileptic seizures. | [Synthesis]
4-Nitropyrazole (1.13 g, 10 mmol) was dissolved in methanol (10 mL) under hydrogen (1 atm) atmosphere and 10% Pd-C catalyst (0.1 g) was added. The reaction mixture was stirred at 25 °C for 12 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford the target product 4-aminopyrazole (860 mg, yield: 100%), which could be used in subsequent reactions without further purification. | [References]
[1] Patent: US2015/336982, 2015, A1. Location in patent: Paragraph 0252; 0253
[2] ChemMedChem, 2016, p. 1695 - 1699
[3] Patent: CN105418616, 2016, A. Location in patent: Paragraph 0118; 0119
[4] Organic and Biomolecular Chemistry, 2013, vol. 11, # 3, p. 395 - 399
[5] Patent: WO2017/178510, 2017, A1. Location in patent: Page/Page column 297 |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Adamas Reagent, Ltd.
|
| Telephone: |
4006009262 13023226327 |
| Website: |
http://www.tansoole.com |
| Company Name: |
Shanghai Ennopharm Co., Ltd.
|
| Telephone: |
+86 (21) 6435-5022 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList13640/0_EN.htm |
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