| Identification | More | [Name]
3-Aminopyrazole | [CAS]
1820-80-0 | [Synonyms]
1H-PYRAZOL-3-AMINE
1H-PYRAZOL-3-YLAMINE
3-AMINO-1H-PYRAZOLE
3-AMINOPYRAZOLE
3-PYRAZOLAMINE
5-AMINOPYRAZOLE
AKOS B007331
3-Aminopyarazole
pyrazol-3-ylamine
3-AMINOPYROZOLE
3-AMINOPYRAZOL
1H-Pyrazol-3-amin
3-Amino-1H-pyrazole 97%
3(5)-Aminopyrazole
3-AMINOPYRAZOLE,99+%
1H-pyrazole-5-amine
5-amino-1H-pyrazole
(5-1H-Pyrazolyl)amine
5-Pyrazolamine
3-Aminopyrazole ,98% | [EINECS(EC#)]
217-338-1 | [Molecular Formula]
C3H5N3 | [MDL Number]
MFCD00005236 | [Molecular Weight]
83.09 | [MOL File]
1820-80-0.mol |
| Chemical Properties | Back Directory | [Appearance]
Low-Melting Yellow Solid | [Melting point ]
34-37 °C (lit.) | [Boiling point ]
218 °C/122 mmHg (lit.) | [density ]
1.0248 (rough estimate) | [refractive index ]
1.5060 (estimate) | [Fp ]
>230 °F
| [storage temp. ]
2-8°C
| [solubility ]
soluble in Methanol | [form ]
Oily Liquid or Crystalline Low Melting Solid | [pka]
15.28±0.10(Predicted) | [color ]
White to light yellow | [Sensitive ]
Air & Light Sensitive | [Usage]
Used in the preparation of heterocyclic compounds of pharamaceutical interest | [Detection Methods]
GC.NMR | [BRN ]
1618 | [InChI]
1S/C3H5N3/c4-3-1-2-5-6-3/h1-2H,(H3,4,5,6) | [InChIKey]
JVVRJMXHNUAPHW-UHFFFAOYSA-N | [SMILES]
Nc1cc[nH]n1 | [CAS DataBase Reference]
1820-80-0(CAS DataBase Reference) | [NIST Chemistry Reference]
3(5)-aminopyrazole(1820-80-0) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS05,GHS07 | [Signal word ]
Danger | [Hazard statements ]
H302-H314 | [Precautionary statements ]
P260-P270-P280-P301+P312-P303+P361+P353-P305+P351+P338 | [Hazard Codes ]
C,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R34:Causes burns.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S27:Take off immediately all contaminated clothing . | [RIDADR ]
UN 3263 8/PG 2
| [WGK Germany ]
3
| [F ]
8-10-23 | [Hazard Note ]
Corrosive | [REACH Registrations]
Active | [HazardClass ]
8 | [HazardClass ]
IRRITANT | [PackingGroup ]
Ⅱ | [HS Code ]
29331900 | [Storage Class]
8A - Combustible corrosive hazardous materials | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Dam. 1
Skin Corr. 1B |
| Raw materials And Preparation Products | Back Directory | [Preparation Products]
4-Chloro-2-methylthiopyrazolo[1,5-a]1,3,5-triazine-->1H-Pyrazolo[3,4-b]pyridin-3-amine-->1H-Pyrazolo[3,4-b]pyridine, 3-bromo--->3-Nitro-1H-pyrazolo[3,4-b]pyridine-->8-Bromo-4-chloro-2-methylthiopyrazolo[1,5-a]1,3,5-triazine-->1H-Pyrazolo[3,4-b]pyridine-->5-Bromo-1H-pyrazo[3,4-b]pyridine-->3-Acetylaminopyrazole-->3-Amino-4-bromopyrazole-->5-Nitro-1H-pyrazolo[3,4-b]pyridine-->3-AMino-4-iodo-1H-pyrazole, 97%-->1174229-22-1-->1-(4-Fluoro-benzyl)-1H-pyrazol-3-ylamine-->1-{[4-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-amine-->7-Methylpyrazolo[1,5-a]pyriMidin-5(4H)-one |
| Hazard Information | Back Directory | [Chemical Properties]
3-Aminopyrazole is Low-Melting Yellow Solid
| [Uses]
3-Aminopyrazole is used in the preparation of heterocyclic compounds of pharamaceutical interest
| [Uses]
Employed in a one-pot synthesis of pyrazolopyrimidines.1 | [General Description]
3-Aminopyrazole is a heteroarylamine. | [Synthesis]
The synthesis of 3-Aminopyrazole is as follows:A solution of 50 mg (0.34 mmol) of 3-oxo-3-phenylpropanenitrile and 11.6 mg (0.36 mmol) of hydrazine and 0.024 mL of acetic acid (0.37 mmol) in 3 mL of anhydrous ethanol was heated at 60° C for 24 hr. The mixture was cooled to ambient temperature and the solvent removed in vacuo. The residue was taken up in ethyl acetate, washed with saturated sodium bicarbonate. The organic layer was washed with brine and dried over MgSO4, filtered and evaporated. The solid residue waswashedwithethyl ether and dried in vacuo to give 45 mg (82%) of 3-phenyl-1H-pyrazol-5-amine. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|