| Identification | Back Directory | [Name]
COP-1 | [CAS]
28704-27-0 | [Synonyms]
COP-1
poly(ala
Copaxone
(t,g)-a-l
[L-ALA, L-GLU, L-LYS HBR, L-TYR]N
(l-ala, l-glu, l-lys, l-tyr)n ·hbr
POLY(ALA, GLU, LYS, TYR) HYDROBROMIDE
poly(alanine-glutamic acid-lysine-tyrosine)
COP-1, (L-Ala, L-Glu, L-Lys, L-Tyr)n HBr
poly(ala, glu, lys, tyr) 6:2:5:1 hydrobromide
POLY(ALA, GLU, LYS, TYR) 6:2:5:1*HYDROBR OMIDE MOL.
Poly(Ala, Glu, Lys, Tyr) 6:2:5:1 hydrobromide Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000 | [Molecular Formula]
C23H41N5O11 | [MDL Number]
MFCD00166401 | [MOL File]
28704-27-0.mol | [Molecular Weight]
563.61 |
| Hazard Information | Back Directory | [Description]
Copaxone was launched in Israel and the US for treatment of relapsingremitting
multiple sclerosis. The amino acid polymer is prepared from the Ncarboxyanhydrides
of Tyr, Ala, γ-benzylglutamate and ε,N-trifluoroacetyllysine followed
by deprotection. Structurally, the random polymer, with a residue molar ratio of
6.0:1.9:4.7:1.O=Ala:Glu:Lys:Tyr, simulates myelin basic protein (MBP). This gives it
immunomodulating and immunosuppressive activity (antigen specific so not a general
immunosuppressive). The mechanism involves binding to MHC class Ⅱ (I-A/DR)
molecules which results both in competition with myelin antigens for T-cell activation
and in induction of specific suppressor cells of the Th2 type. Therefore, the antigenspecific
interaction gives rise to a reduced probability of long-term damage to the
immune system. The competition with MBP and other myelin-associated antigens
inhibits T-cell responses to MBP, and the binding occurs with high efficiency, fast rates
and is non-species specific. It resulted in a 29% reduction in relapse rate and is most
effective in patients with less accumulated neurologic disability. | [Originator]
Yeda (Israel) | [Brand name]
Copaxone |
|
| Company Name: |
Cipla Ltd
|
| Tel: |
+912224826000 |
| Website: |
www.cipla.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|