| Identification | Back Directory | [Name]
4-Isothiazolecarbonitrile, 2,3-dihydro-3-oxo-5-[[2-(trifluoromethyl)phenyl]amino]- | [CAS]
287196-91-2 | [Synonyms]
4-Isothiazolecarbonitrile,2,3-dihydro-3-oxo-5-[[2-(trifluoromethyl)phenyl]a
3-Oxo-5-[[2-(trifluoromethyl)phenyl]amino]-2,3-dihydroisothiazole-4-carbonitrile
4-Isothiazolecarbonitrile, 2,3-dihydro-3-oxo-5-[[2-(trifluoromethyl)phenyl]amino]- | [Molecular Formula]
C11H6F3N3OS | [MOL File]
287196-91-2.mol | [Molecular Weight]
285.24 |
| Hazard Information | Back Directory | [Uses]
3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles is an inhibitor for bone morphogenetic protein 2 (BMP2) with an IC50 of 2.2 μM. 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles is inhibitor for mitogen-activated protein kinase 1 (MEK1). 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles exhibits anti-inflammatory and neuroprotective activity in EAE mouse model[1][2]. | [References]
[1] Arnon KARNI, Small organic molecules for use in the treatment of neuroinflammatory disorders. WO2018198123.
[2] Varaprasad CV, et al., Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors. Bioorg Med Chem Lett. 2006 Aug 1;16(15):3975-80. DOI:10.1016/j.bmcl.2006.05.019 |
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