| Identification | Back Directory | [Name]
2-Propenoic acid, 2-cyano-3-[1-[2-[(4-methoxyphenyl)amino]-2-oxoethyl]-1H-indol-3-yl]-, methyl ester | [CAS]
2878360-80-4 | [Synonyms]
MCT1IN3
MCT1-IN-3
2-Propenoic acid, 2-cyano-3-[1-[2-[(4-methoxyphenyl)amino]-2-oxoethyl]-1H-indol-3-yl]-, methyl ester | [Molecular Formula]
C22H19N3O4 | [MOL File]
2878360-80-4.mol | [Molecular Weight]
389.4 |
| Hazard Information | Back Directory | [Uses]
MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor with an IC50 value of 81.0 nM. MCT1-IN-3 has also significant inhibitivity against the multidrug transporter ABCB1. MCT1-IN-3 can be used for the research of cancer[1]. | [References]
[1] Sachin Puri, et al. Indole Derivatives as New Structural Class of Potent and Antiproliferative Inhibitors of Monocarboxylate Transporter 1 (MCT1; SLC16A1). J Med Chem. 2023 Jan 12;66(1):657-676. DOI:10.1021/acs.jmedchem.2c01612 |
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