| Identification | Back Directory | [Name]
SB408124 | [CAS]
288150-92-5 | [Synonyms]
CS-1990
SB 408124
SB 408214
SB408124 USP/EP/BP
SB 408124; SB408124
SB-408124, CID4331799
SB-408124 >=98% (HPLC), solid
1-(6,8-difluoro-2-methylquinolin-4-yl)-3-(4-(dimethylamino)phenyl)urea
N-(6,8-DIFLUORO-2-METHYL-4-QUINOLINYL)-N'-[4-(DIMETHYLAMINO)PHENYL]UREA
Urea, N-(6,8-difluoro-2-methyl-4-quinolinyl)-N'-[4-(dimethylamino)phenyl]-
SB 4081241-(6,8-difluoro-2-methylquinolin-4-yl)-3-(4-(dimethylamino)phenyl)urea | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C19H18F2N4O | [MDL Number]
MFCD06411575 | [MOL File]
288150-92-5.mol | [Molecular Weight]
356.37 |
| Chemical Properties | Back Directory | [Boiling point ]
430.3±45.0 °C(Predicted) | [density ]
1.371 | [storage temp. ]
2-8°C
| [solubility ]
DMSO: ~24 mg/mL
| [form ]
solid
| [pka]
12.12±0.43(Predicted) | [color ]
olive-green
|
| Hazard Information | Back Directory | [Uses]
SB 408124 is a novel OX-1 antagonist. | [Definition]
ChEBI: 1-(6,8-difluoro-2-methyl-4-quinolinyl)-3-[4-(dimethylamino)phenyl]urea is a member of quinolines and an organohalogen compound. | [Biological Activity]
Selective non-peptide orexin OX 1 receptor antagonist (K b values are 21.7 and 1405 nM for human OX 1 and OX 2 receptors respectively). Blocks orexin-A induced grooming following oral administration in vivo . | [storage]
Store at RT | [References]
[1] langmead cj1, jerman jc, brough sj, scott c, porter ra, herdon hj.characterisation of the binding of [3h]-sb-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. br j pharmacol. 2004 jan;141(2):340-6.
[2] woldan-tambor a1, biegańska k, wiktorowska-owczarek a, zawilska jb. activation of orexin/hypocretin type 1 receptors stimulates camp synthesis in primary cultures of rat astrocytes. pharmacol rep. 2011;63(3):717-23.
[3] kis gk1, molnár ah, daruka l, gardi j, rákosi k, lászló f, lászló fa, varga c.the osmotically and histamine-induced enhancement of the plasma vasopressin level is diminished by intracerebroventricularly administered orexin in rats. pflugers arch. 2012 apr;463(4):531-6. |
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