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289893-25-0

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289893-25-0 Structure

289893-25-0 Structure
IdentificationBack Directory
[Name]

(2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol
[CAS]

289893-25-0
[Synonyms]

arimoclomol
Amrioclomol
Pefcalcitol
BRX-220 free base
(2R-)Arimoclomol NEW
(2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol
3-Pyridinecarboximidoyl chloride, N-[(2R)-2-hydroxy-3-(1-piperidinyl)propoxy]-, 1-oxide
[Molecular Formula]

C14H20ClN3O3
[MDL Number]

MFCD16660939
[MOL File]

289893-25-0.mol
[Molecular Weight]

313.78
Chemical PropertiesBack Directory
[Melting point ]

93 - 95o C
[Boiling point ]

539.2±60.0 °C(Predicted)
[density ]

1.32±0.1 g/cm3(Predicted)
[storage temp. ]

Hygroscopic, -20°C Freezer, Under inert atmosphere
[solubility ]

Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
[form ]

Solid
[pka]

14.03±0.20(Predicted)
[color ]

White to Off-White
[Stability:]

Hygroscopic
Safety DataBack Directory
[Symbol(GHS) ]

Flame (GHS02)
GHS02
[Signal word ]

Danger
[Hazard statements ]

H261
[Precautionary statements ]

P223-P231+P232-P280-P335+P334-P370+P378-P402+P404-P501
Hazard InformationBack Directory
[Uses]

Arimoclomol is a co-inducer of HSP that acts through heat shock factor 1 (HSF1) in cells undergoing cellular stress. Has therapeutic potential in motor neuron degenerative diseases. Potential treatment for liposomal storage disorders, such as Niemann-Pick disease type C.
[in vivo]

Arimoclomol (BRX-220; 20 mg/kg; orally administered for 5 d) has a protective effect against cholecystokinin-octapeptide (CCK)-induced acute pancreatitis[1].

Animal Model:Male Wistar rats weighing 240 to 270 g[1]
Dosage:20 mg/kg
Administration:Administered intragastrically, for 5 days
Result:Had a protective effect against CCK-induced acute pancreatitis.
[IC 50]

HSP
Spectrum DetailBack Directory
[Spectrum Detail]

(2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol(289893-25-0)1HNMR
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