| Identification | Back Directory | [Name]
butropium bromide | [CAS]
29025-14-7 | [Synonyms]
BHB
Coliopan
Butropan
Butropium
[3(S)-endo]-
butropium bromide
butoxybenzyl hyoscyamine
N-(Butoxybenzyl)hyoscyamine bromide
(p-Butoxybenzyl)hyoscyaminium bromide
1αH,5αH-Tropanium, 8-(p-butoxybenzyl)-3α-hydroxy-, bromide, (-)-tropate (8CI)
8-Azoniabicyclo[3.2.1]octane, 8-[(4-butoxyphenyl)methyl]-3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-, bromide, [3(S)-endo]- | [EINECS(EC#)]
249-375-4 | [Molecular Formula]
C28H38NO4.Br | [MDL Number]
MFCD01741617 | [MOL File]
29025-14-7.mol | [Molecular Weight]
532.515 |
| Chemical Properties | Back Directory | [Melting point ]
166-168oC | [alpha ]
D20 -21.7° (c = 0.5 in water) | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Slightly), Methanol (Slightly, Sonicated) | [form ]
Solid | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Chemical Properties]
Crystalline Solid | [Originator]
Coliopan,Eisai,Japan,1974 | [Uses]
Anticholinergic. Antispasmodic. | [Definition]
ChEBI: Butropium bromide is an organic bromide salt of butropium. It is a drug which suppresses spasm of smooth muscles of internal organs, inhibits gastric acid secretion and relieves abdominal pain. It is used in the treatment of spasmodic pains associated with gastritis, gastric ulcers and cholelithiasis. It has a role as an antispasmodic drug and a muscarinic antagonist. It is an organic bromide salt and a quaternary ammonium salt. It contains a butropium. | [Manufacturing Process]
To 100 ml of an isopropanol solution containing 11.8 grams of hyoscyamine
base were added drop by drop with stirring 10 ml of an isopropanol solution
containing 11 grams of p-n-butoxybenzyl bromide. After a while, the reaction
mixture had a turbid appearance followed by separation of white crystals.
After stirring for 5 hours at room temperature, the crystals were recovered by
filtration, which were then recrystallized from 120 ml of isopropanol. There
was obtained 15.8 grams of white needles having the melting point of 158°-
160°C. | [Therapeutic Function]
Spasmolytic |
|
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