| Chemical Properties | Back Directory | [Boiling point ]
607.9±55.0 °C(predicted) | [density ]
1.422±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [solubility ]
DMSO: Sparingly soluble: 1-10 mg/ml | [form ]
Solid | [pka]
10.91±0.70(predicted) | [color ]
Light yellow to brown |
| Hazard Information | Back Directory | [Uses]
USP28-IN-4 is a USP28 inhibitor (IC50=0.04 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-4 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-4 also decreases the ankyrase-1/2 level in vitro. USP28-IN-4 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331)[1]. | [IC 50]
USP28: 0.04 μM (IC50) | [References]
[1] Zhou D, et al. Structure-based discovery of potent USP28 inhibitors derived from Vismodegib. Eur J Med Chem. 2023 Jun 5;254:115369. DOI:10.1016/j.ejmech.2023.115369 |
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