| Identification | Back Directory | [Name]
Jatrophone | [CAS]
29444-03-9 | [Synonyms]
NSC135037
NSC-135037
Jatrophone
NSC 135037
Jatropha principle
(2R,3aR,9E,12Z)-2,3,7,8-Tetrahydro-2,5,8,8,12-pentamethyl-3a,6-epoxy-3aH-cyclopentacyclododecene-4,11-dione
3a,6-Epoxy-3aH-cyclopentacyclododecene-4,11-dione, 2,3,7,8-tetrahydro-2,5,8,8,12-pentamethyl-, (2R,3aR,9E,12Z)- | [Molecular Formula]
C20H24O3 | [MDL Number]
MFCD09837890 | [MOL File]
29444-03-9.mol | [Molecular Weight]
312.4 |
| Chemical Properties | Back Directory | [Definition]
A diterpenoid growth inhibitor isolated from an alcohol extract of the plant Jatropha gossypiifolia. Its unique structure includes a 12membered ring. It is readily attacked by nucleophiles. Useful in study of tumor growth inhibition and other biochemica |
| Hazard Information | Back Directory | [Uses]
Jatrophone is a diterpenoid with anticancer activity isolated from Jatropha isabelli. Jatrophone interferes with the Wnt/β-catenin pathway to inhibit the proliferation and epithelial-mesenchymal transition (EMT) of triple-negative breast cancer cells. | [References]
[1] The natural compound Jatrophone interferes with Wnt/β-catenin signaling and inhibits proliferation and EMT in human triple-negative breast cancer |
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