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NLRP3-IN-58 (Compound DS15) is an inhibitor for the activation of NLRP3 inflammasome with an IC50 of 3.85 μM, and inhibits 33% IL-1β release at a concentration of 10 μM[1]. | [References]
[1] El-Sayed S, et al., Virtual screening-led design of inhibitor scaffolds for the NLRP3 inflammasome. Bioorg Chem. 2024 Oct 22;153:107909. DOI:10.1016/j.bioorg.2024.107909 |
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