| Identification | More | [Name]
2-Amino-2',5-dichlorobenzophenone | [CAS]
2958-36-3 | [Synonyms]
2-AMINO-2',5-DICHLOROBENZOPHENONE
2-AMINO-5,2'-DICHLORO BENZOPHENONE
2-AMINO-5-CHLORO-2'-CHLOROBENZOPHENONE
2'-AMINO-5'-CHLOROBENZOYL-2-CHLOROBENZENE
(2-AMINO-5-CHLOROPHENYL)(2-CHLOROPHENYL)METHANONE
IFLAB-BB F1386-0354
LABOTEST-BB LT00080738
LORAZEPAM IMP A
LORAZEPAM IMPURITY A
TIMTEC-BB SBB003068
(2-amino-5-chlorophenyl)(2-chlorophenyl)-methanon
2-amino-2’,5-dichloro-benzophenon
2-amino-5,2'-dichlor-benzophenone
Benzophenone, 2-amino-2',5-dichloro-
2-Amino-2-dichlorobenzophenone
2-Amino-2',5-dichlorobenzophenone,99%
2',5-Dichloro-2-aminobenzophenone
2,5'-Dichloro-2'-aminobenzophenone
NSC 611905
Methanone, (2-amino-5-chlorophenyl)(2-chlorophenyl)- | [EINECS(EC#)]
220-985-2 | [Molecular Formula]
C13H9Cl2NO | [MDL Number]
MFCD00007840 | [Molecular Weight]
266.12 | [MOL File]
2958-36-3.mol |
| Chemical Properties | Back Directory | [Appearance]
YELLOW TO YELLOW-GREEN POWDER | [Melting point ]
87-89 °C(lit.)
| [Boiling point ]
453.6±40.0 °C(Predicted) | [density ]
1.3134 (rough estimate) | [vapor pressure ]
0Pa at 25℃ | [refractive index ]
1.5490 (estimate) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
methanol: soluble | [form ]
neat | [pka]
-0.97±0.10(Predicted) | [color ]
Yellow to Green | [Water Solubility ]
Insoluble in water. | [Usage]
Lorazepam Impurity A. | [BRN ]
652774 | [InChI]
1S/C13H9Cl2NO/c14-8-5-6-12(16)10(7-8)13(17)9-3-1-2-4-11(9)15/h1-7H,16H2 | [InChIKey]
KWZYIAJRFJVQDO-UHFFFAOYSA-N | [SMILES]
Nc1ccc(Cl)cc1C(=O)c2ccccc2Cl | [LogP]
3.1 | [CAS DataBase Reference]
2958-36-3(CAS DataBase Reference) | [NIST Chemistry Reference]
Methanone, (2-amino-5-chlorophenyl)(2-chlorophenyl)-(2958-36-3) | [EPA Substance Registry System]
2958-36-3(EPA Substance) |
| Questions And Answer | Back Directory | [Preparation]
At room temperature, 2-amino-5-chlorobenzonitrile (0.4 mmol), 2-chlorophenylboronic acid (0.8 mmol), Pd(O2CCF3)2 (5 mol%), MsOH (10 eq), ligand 5,5'-dimethyl-2,2'-bipyridine (7.5 mol%), 2-methyltetrahydrofuran (2 mL), and H2O (1 mL) were added to a Schlenk tube. The reaction mixture was stirred vigorously at 80 °C for 36 h. The mixture was poured into ethyl acetate, washed with saturated NaHCO3 (2 × 10 mL), and then washed with brine (1 × 10 mL). The aqueous layer was extracted with ethyl acetate, the organic layers were combined and dried over anhydrous Na2SO4, and concentrated under vacuum. The residue was purified by flash column chromatography (using hexane/ethyl acetate as eluent) to give the desired yellow solid product 2-amino-2',5-dichlorobenzophenone (55.3 mg, 52% yield). |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
DJ0200000
| [Hazard Note ]
Irritant | [TSCA ]
Yes | [REACH Registrations]
Active | [HS Code ]
29223900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
YELLOW TO YELLOW-GREEN POWDER | [Uses]
Lorazepam Impurity A. | [General Description]
2-Amino-2′,5-dichlorobenzophenone can be synthesized from a precursor diazepine, Iorazepam. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
China Langchem Inc.
|
| Telephone: |
0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
|