| Chemical Properties | Back Directory | [Boiling point ]
676.038±55.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.246±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [solubility ]
Acetonitrile: Soluble DMSO: Soluble | [form ]
Solid | [pka]
15.425±0.10(predicted) | [color ]
Off-white to yellow |
| Hazard Information | Back Directory | [Uses]
PD-1/PD-L1-IN-33 (Compound N11) is a PD-1/PD-L1 inhibitor. PD-1/PD-L1-IN-33 inhibits PD-1 and PD-L1 interaction with an IC50: 6.3 nM. PD-1/PD-L1-IN-33 promotes T-cell proliferation, activation, and infiltration into tumor spheres. PD-1/PD-L1-IN-33 has immunomodulatory and anticancer activity[1]. | [References]
[1] Yangyang Meng, et al. Novel 4-Arylindolines Containing a Pyrido[3,2-d]pyrimidine Moiety as the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction Inhibitors for Tumor Immunotherapy. J. Med. Chem. 2023. |
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