| Identification | Back Directory | [Name]
2-CHLORO-4-PHENYLQUINAZOLINE | [CAS]
29874-83-7 | [Synonyms]
quinazoL
oro-4-phenyL
2-CHLORO-4-PHENYLQUIZOLINE
2-CHLORO-4-PHENYLQUINAZOLIN
2-CHLORO-4-PHENYLQUINAZOLINE
2-Chloro-4-phenylq inazollne
Quinazoline,2-chloro-4-phenyl-
2-CHLORO-4-PHENYLQUINAZOLINE ISO 9001：2015 REACH | [EINECS(EC#)]
201-615-9 | [Molecular Formula]
C14H9ClN2 | [MDL Number]
MFCD01152724 | [MOL File]
29874-83-7.mol | [Molecular Weight]
240.69 |
| Chemical Properties | Back Directory | [Melting point ]
113.0 to 117.0 °C | [Boiling point ]
347.4±30.0 °C(Predicted) | [density ]
1.285±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [form ]
powder to crystal | [pka]
0.24±0.30(Predicted) | [color ]
White to Orange to Green |
| Hazard Information | Back Directory | [Synthesis]
A 2 L flask was charged with 35.0 g (175.8 mmol) of 2,4-dichloroquinoline,22.5 g (184.6 mmol) of phenylboronic acid, 6.1 g (5.3 mmol) of tetrakis(triphenylphosphine)palladium(0) were added to 800 mL of tetrahydrofuran and 400 mL of water, and the mixture was heated to 60 ?? C for 12 hours under a nitrogen stream. . The resulting mixture was added to methanol (3000 mL), and the crystallized solid was filtered and dissolved in toluene, filtered through silica gel / celite, and the organic solvent was removed in an appropriate amount, and then recrystallization from methanol gave Intermediate I-A52-1 (36.8 g, 87% yield). |
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