| Identification | Back Directory | [Name]
3-METHOXY-L-TYROSINE | [CAS]
300-48-1 | [Synonyms]
3-OMD
3-O-methyldopa
3-METHOXY-TYROSINE
3-METHOXY-L-TYROSINE
L-Tyrosine, 3-Methoxy-
3-Methoxy-L-Tyrosine97%
L-3-O-METHYL-DOPA DIHYDRATE
3-METHOXY-L-TYROSINE DIHYDRATE
3-(4-hydroxy-3-methoxyphenyl)-L-alanine
L-3-(4-hydroxy-3-methoxyphenyl)-alanine
4-HYDROXY-3-METHOXY-L-PHENYLALANINE DIHYDRATE
(S)-2-aMino-3-(4-hydroxy-3-Methoxyphenyl)propanoic acid
(2S)-2-amino-3-(4-hydroxy-3-methoxyphenyl)propanoic acid
(2S)-2-amino-3-(4-hydroxy-3-methoxy-phenyl)propionic acid
(2S)-2-azanyl-3-(4-hydroxy-3-methoxy-phenyl)propanoic acid | [Molecular Formula]
C10H13NO4 | [MDL Number]
MFCD00037205 | [MOL File]
300-48-1.mol | [Molecular Weight]
211.21 |
| Chemical Properties | Back Directory | [Boiling point ]
407.3±45.0 °C(Predicted) | [density ]
1.321±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [form ]
powder
| [pka]
2.24±0.20(Predicted) | [color ]
off-white to yellow
| [Water Solubility ]
Water: 16.67 mg/mL (78.93 mM) |
| Hazard Information | Back Directory | [Uses]
3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine[1]. | [Definition]
ChEBI: 3-O-methyldopa is a L-tyrosine derivative that is the 3-methoxy derivative of L-dopa. It has a role as a human metabolite. It is a L-tyrosine derivative, a monomethoxybenzene and a non-proteinogenic L-alpha-amino acid. It is functionally related to a L-dopa. It is a tautomer of a 3-O-methyldopa zwitterion. | [References]
[1] Masato Asanuma, et al. 3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of L-DOPA. BMC Neurosci. 2016 Jul 25;17(1):52. DOI:10.1186/s12868-016-0289-0 |
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