| Identification | More | [Name]
LEAD ACETATE | [CAS]
301-04-2 | [Synonyms]
ACETIC ACID LEAD SALT
ACETIC ACID, LEAD SALT TRIHYDRATE
LEAD(+2)ACETATE TRIHYDRATE
LEAD ACETATE
LEAD ACETATE 3H2O
LEAD ACETATE-3-HYDRATE
LEAD ACETATE HYDRATED
LEAD ACETATE PAPER
LEAD ACETATE, TRIHYDRATE
LEAD ACETATE TS
LEAD ACETATE TS, ALCOHOLIC
LEAD (II) ACETATE
LEAD(II) ACETATE 3-HYDRATE
LEAD (II) ACETATE, HYDROUS
LEAD(II) ACETATE TRIHYDRATE
LEAD SUGAR
acetatedeplomb
acetatedeplomb(french)
aceticacid,lead(2+)salt
aceticacid,lead(2++)salt | [EINECS(EC#)]
206-104-4 | [Molecular Formula]
C4H6O4Pb | [MDL Number]
MFCD00012452 | [Molecular Weight]
325.29 | [MOL File]
301-04-2.mol |
| Chemical Properties | Back Directory | [Description]
Lead
acetate is stable under ordinary conditions of use and storage. Lead acetate is incompatible
with bromates, phenol, chloral hydrate, sulphides, hydrogen peroxide, resorcinol,
salicylic acid, sulphites, vegetable infusions, alkalis, tannin, phosphates, citrates, chlorides,
carbonates, tartrates, and acids. Lead (II) acetate, as well as white lead, has been
used in cosmetics throughout history, though this practice has ceased in Western countries.
It is still used in men’s hair colouring. Lead (II) acetate paper is used to detect the
poisonous gas hydrogen sulphide. The gas reacts with lead (II) acetate on the moistened
test paper to form a grey precipitate of lead (II) sulphide. | [Appearance]
Lead acetate is a white, flaky crystalline substance with a slight odor of acetic acid. Commercial grades
may be powdered granules, or brown or gray lumps.
Diacetate: Powder. | [Melting point ]
75 °C (dec.)(lit.)
| [Boiling point ]
decomposes at >280℃ [KIR78] | [density ]
3.3 g/cm3 | [vapor pressure ]
15.7hPa at 25℃ | [storage temp. ]
2-8°C
| [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Liquid | [color ]
Clear colorless | [Water Solubility ]
g/100g H2O: 19.7 (0°C), 55.2 (25°C); equilibrium solid phase, Pb(CH3COO)2 ·3H2O [KRU93]; g/100mL H2O: 44.3 (20°C), 221 (50°C) [KIR78] | [λmax]
260nm(H2O)(lit.) | [Merck ]
14,5397 | [Solubility Product Constant (Ksp)]
pKsp: 2.75 | [Dielectric constant]
2.5（0.0℃） | [LogP]
-0.17 | [Uses]
Mordant in cotton dyes; lead coating for metals; drier in paints, varnishes and pigment inks; colorant in hair dyes; once used therapeutically as an astringent. | [CAS DataBase Reference]
301-04-2(CAS DataBase Reference) | [EPA Substance Registry System]
Lead(II) acetate (301-04-2) |
| Hazard Information | Back Directory | [Chemical Properties]
Lead acetate is a white, flaky crystalline substance with a slight odor of acetic acid. Commercial grades
may be powdered granules, or brown or gray lumps.
Diacetate: Powder. | [Definition]
ChEBI: A lead coordination entity in which a central lead(2+) atom is coordinated to two acetate ions. | [Uses]
Mordant in cotton dyes; lead coating for metals; drier in paints, varnishes and pigment inks; colorant in hair dyes. Weighting silks; manufacture of lead salts, chrome-yellow; as analytical reagent for detection of sulfide, determination of CrO3, MoO3. | [Potential Exposure]
Lead acetate is used as a color additive in hair dyes; as a mordant in cotton dyes, in the lead
coating of metals; as a drier in paints; varnishes and pigment inks; and in medicinals, such as astringents.
Incompatibilities: A strong reducing agent. Reacts violently
with strong oxidizers, bromates, strong acids; chemically
active metals; phosphates, carbonates, phenols. Contact
with strong acids forms acetic acid. Incompatible with
strong bases: ammonia, amines, cresols, isocyanates, alkylene oxides; epichlorohydrin, sulfites, resorcinol, salicylic
acid, and chloral hydrat | [First aid]
Skin Contact: Flood all areas of body that
have contacted the substance with water. Do not wait to
remove contaminated clothing; do it under the water
stream. Use soap to help assure removal. Isolate contaminated clothing when removed to prevent contact by others.
Eye Contact: Remove any contact lenses at once.
Immediately flush eyes well with copious quantities of
water or normal saline for at least 2030 minutes. Seek
medical attention. Inhalation: Leave contaminated area
immediately; breathe fresh air. Proper respiratory protection
must be supplied to any rescuers. If coughing, difficult
breathing or any other symptoms develop, seek medical
attention at once, even if symptoms develop many hours
after exposure. Ingestion: Contact a physician, hospital or
poison center at once. If the victim is unconscious or convulsing, do not induce vomiting or give anything by mouth.
Assure that the patient’s airway is open and lay him on his
side with his head lower than his body and transport immediately to a medical facility. If conscious and not convulsing, give a glass of water to dilute the substance. Vomiting
should not be induced without a physician’s advice | [Shipping]
UN1616 Lead acetate, Hazard Class: 6.1;
Labels: 6.1-Poisonous materials | [Incompatibilities]
A strong reducing agent. Reacts violently
with strong oxidizers, bromates, strong acids; chemically
active metals; phosphates, carbonates, phenols. Contact
with strong acids forms acetic acid. Incompatible with
strong bases: ammonia, amines, cresols, isocyanates, alkylene oxides; epichlorohydrin, sulfites, resorcinol, salicylic
acid, and chloral hydrate | [Waste Disposal]
Convert to nitrate using nitric
acid; evaporate, then saturate with H2S; wash and dry
the sulfide and ship to the supplier. Consult with
environmental regulatory agencies for guidance on
acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with
EPA regulations governing storage, transportation, treatment, and waste disposal | [Production Methods]
Lead acetate is made by dissolving lead monoxide (litharge) or lead carbonate in strong acetic acid. Several types of basic salts are formed when lead acetates are prepared from lead monoxide in dilute acetic acid or at high pH. The basic salts of lead acetate are white crystalline compounds, which are highly soluble in water and dissolve in ethyl alcohol.
Lead acetate can be made by boiling elemental lead in acetic acid and hydrogen peroxide. | [Purification Methods]
Crystallise it twice from anhydrous acetic acid and dry it under vacuum for 24hours at 100o. The solubility in H2O is 63% (at ~20o) and 200% (at boiling point). [Beilstein 2 IV 118.] | [Flammability and Explosibility]
Notclassified | [storage]
Color Code- Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handlingandstorage. Store in a cool, dry place and keep tightly coveredand avoid contact with oxidizers, strong acids, chemicallyactive metals. A regulated, marked area should be estab-lished where this chemical is handled, used, or stored incompliance with OSHA Standard 1910.1045. | [Precautions]
Lead (II) acetate, as with any other lead salts, causes lead poisoning. |
| Safety Data | Back Directory | [Hazard Codes ]
T,N | [Risk Statements ]
R61:May cause harm to the unborn child.
R33:Danger of cumulative effects.
R48/22:Harmful: danger of serious damage to health by prolonged exposure if swallowed .
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R62:Possible risk of impaired fertility. | [Safety Statements ]
S53:Avoid exposure-obtain special instruction before use .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S60:This material and/or its container must be disposed of as hazardous waste .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
UN 1616 6.1/PG 3
| [WGK Germany ]
2
| [RTECS ]
OF8050000
| [HS Code ]
2915.29.5000 | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [Hazardous Substances Data]
301-04-2(Hazardous Substances Data) |
| Questions And Answer | Back Directory | [Physical Properties]
Lead(II) acetate, Pb(CH3COO)2, is a white crystalline material with a sweet taste and is also classified by one of the following trivial names: lead sugar, Saturn salt and Goulard powder, respectively. Lead acetate is water and glycerin soluble, and is toxic (like most lead compounds).
The anhydrous salt is a white crystalline solid; very sweet taste; density 3.25 g/cm3 at 20°C; melts at 280°C; very soluble in cold water (44.39g/100g at 20°C); solubility is much greater in hot water (221g/100g at 50°C; also soluble in alcohols.
The trihydrate is a colorless monoclinic crystal or white granule or powder; refractive index 1.567 (along the beta axis); faint vinegar odor; intense sweet taste and then metallic after-taste; slowly effloresces; density 2.55 g/cm3; melts at 75°C upon rapid heating; loses some of its water of crystallization on heating which dissolves in it; decomposes at 200°C; highly soluble in water (45.61g/100g at 15°C and 200g/100g at 100°C); insoluble in alcohol.
The decahydrate is white rhombic crystal; density 1.69 g/cm3; melts at 22°C; soluble in water but insoluble in alcohol. | [Uses]
Lead (II) acetate, as well as white lead, have been used in cosmetics throughout history, though this practice has ceased in Western countries . It is still used in men's hair coloring products like Grecian Formula.
Lead acetate is used as a reagent to make other lead compounds and as a fixative for some dyes. In low concentrations, it is the principal active ingredient in progressive types of hair colouring dyes. These products are applied over a period of time to achieve a gradual coloring effect. Lead (Il) acetate is also used as a mordant in textile printing anddyeing,and as a drier in paints and varnishes.
Lead (II) acetate paper is used to detect the poisonous gas hydrogen sulfide. The gas reacts with lead (II) acetate on the moistened test paper to form a grey precipitate of lead (II) sulfide.
Lead (II) acetate solution was a commonly used folk remedy for sore nipples . In modern medicine, for a time, it was used as an astringent, in the form of Goulard's Extract.
An aqueous solution of lead (II) acetate is the by product of the 50 / 50 mixture of hydrogen peroxide and white vinegar used in the cleaning and maintenance of stainless steel fire arm suppressors (silencers) and compensators. The solution is agitated by the bubbling action of the hydrogen peroxide, and the main reaction is the dissolution of lead deposits within the suppressor by the acetic acid, which forms lead acetate.
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Masterly's Series LAB MANUAL OF PHARMACEUTICS-I For Diploma Pharmacy First | [Preparation]
Lead acetate is prepared by dissolving lead monoxide in strong acetic acid:
PbO + 2CH3COOH → Pb(C2H4O2)2 + H2O
The trihydrate is obtained by dissolving lead monoxide in hot dilute acetic acid solution. Upon cooling, large crystals separate out.
| [Reactions]
Exposure to carbon dioxide yields basic lead carbonate, 2PbCO3•Pb(OH)2, the composition of which may vary with reaction conditions.
Reactions with sulfuric acid, hydrochloric acid and hydriodic acid yield lead sulfate PbSO4, lead chloride PbCl2, and lead iodide PbI2, respectively.
Reaction with hydrogen sulfide forms black precipitate of lead sulfide, PbS. A paper soaked with lead acetate solution turns black on exposure to H2S, a test often used to detect sulfide.
| [Toxicity]
Moderately toxic by intraperitoneal route and possibly by oral route.
LD50 intraperitoneal (mouse):400 mg/kg
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