| Chemical Properties | Back Directory | [density ]
1.410±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
14.217±0.40(predicted) | [color ]
White to light yellow | [InChIKey]
DPKDQKDHUDKBNH-UHFFFAOYSA-N | [SMILES]
C(N1C2=CC=C3C4=CSC(CC(C(N5C6CC(C6)C(N5)C(OCC(CC(C2=C3)=C1C1C=C(N2CCN(CC2)C)C=NC=1C(C)OC)(C)C)=O)=O)NC(C1C(C1C)C)=O)=N4)C |
| Hazard Information | Back Directory | [Uses]
Pan-rasin-2 (compound 6A) is a molecular glues that targets RAS. Pan-rasin-2 has significant inhibitory activity on cell proliferation of RAS mutant cell lines. Pan-rasin-2 can form ternary complexes with cyclophilin A (CYPA) and RAS (ON) proteins and the formation of ternary complexes can block the binding of RAF downstream of RAS, which has anti-tumor effects[1]. | [References]
[1] Y Zhang, et al. Macrocyclic derivative and use thereof. WO2024067857A1. 2023-09-28 |
|
|