| Identification | Back Directory | [Name]
Coumarin, 3-(N-benzylacetimidoyl)-4-hydroxy-, (E)- (8CI) | [CAS]
30408-07-2 | [Synonyms]
JB002
(E)-3-(1-(Benzylimino)ethyl)-4-hydroxy-2H-chromen-2-one
Coumarin, 3-(N-benzylacetimidoyl)-4-hydroxy-, (E)- (8CI) | [Molecular Formula]
C18H15NO3 | [MOL File]
30408-07-2.mol | [Molecular Weight]
293.32 |
| Chemical Properties | Back Directory | [Boiling point ]
457.9±45.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
4.50±1.00(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
JB002 is a myosin II inhibitor, with an IC50 of ≤10 μM. JB002 can be used for the research of muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy[1]. | [References]
[1] Smith JD, et, al. Isoform selectivities of novel 4-hydroxycoumarin imines as inhibitors of myosin II. Eur J Med Chem. 2022 Dec 12;247:115008. DOI:10.1016/j.ejmech.2022.115008 |
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