| Identification | Back Directory | [Name]
Isocoptisine acetate | [CAS]
30426-66-5 | [Synonyms]
Isocoptisine acetate
Pseudocoptisine acetate | [Molecular Formula]
C21H17NO6 | [MDL Number]
MFCD34469516 | [MOL File]
30426-66-5.mol | [Molecular Weight]
379.37 |
| Hazard Information | Back Directory | [Uses]
Pseudocoptisine (Isocoptisine) acetate is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine acetate inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM. Anti-inflammatory and anti-amnestic effects[1][2]. | [in vivo]
The anti-amnesic activities of Pseudocoptisine in mice on the learning and memory impairments induced by scopolamine (1.0 mg/kg, i.p.) are examined. Pseudocoptisine (2.0 mg/kg, p.o.) significantly reverses cognitive impairments in mice by passive avoidance test[1]. | [References]
[1] Hung TM, et al. Anti-amnestic activity of pseudocoptisine from Corydalis Tuber. Biol Pharm Bull. 2008;31(1):159-162. DOI:10.1248/bpb.31.159
[2] Yun KJ, et al. Quaternary alkaloid, pseudocoptisine isolated from tubers of Corydalis turtschaninovi inhibits LPS-induced nitric oxide, PGE(2), and pro-inflammatory cytokines production via the down-regulation of NF-kappaB in RAW 264.7 murine macrophage c DOI:10.1016/j.intimp.2009.08.001 |
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