| Identification | Back Directory | [Name]
TCID | [CAS]
30675-13-9 | [Synonyms]
TCID
TCID USP/EP/BP
UCH-L3 Inhibitor
TCID >=98% (HPLC)
4,5,6,7-TETRACHLOROINDAN-1,3-DIONE
4,5,6,7-TETRACHLOROINDANE-1,3-DIONE
4,5,6,7-Tetrachloro-1,3-indanedione
4,5,6,7-Tetrachloroindane-1,3-dione 95+%
4,5,6,7-TETRACHLORO-1H-INDENE-1,3(2H)-DIONE
1H-Indene-1,3(2H)-dione, 4,5,6,7-tetrachloro-
UCH-L3 Inhibitor - CAS 30675-13-9 - Calbiochem
4,5,6,7-tetrachloro-2,3-dihydro-1H-indene-1,3-dione
4,5,6,7-Tetrachloroindane-1,3-dione
4,5,6,7-Tetrachloroindan-1,3-dione | [Molecular Formula]
C9H2Cl4O2 | [MDL Number]
MFCD00239209 | [MOL File]
30675-13-9.mol | [Molecular Weight]
283.92 |
| Chemical Properties | Back Directory | [Melting point ]
218-220 | [Boiling point ]
448.1±45.0 °C(Predicted) | [density ]
1.782±0.06 g/cm3(Predicted) | [storage temp. ]
+2C to +8C | [solubility ]
Soluble in DMSO (up to 25 mg/ml), | [form ]
Orange solid | [pka]
8.62±0.20(Predicted) | [color ]
White | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. | [InChI]
1S/C9H2Cl4O2/c10-6-4-2(14)1-3(15)5(4)7(11)9(13)8(6)12/h1H2 | [InChIKey]
IDLAOWFFKWRNHB-UHFFFAOYSA-N | [SMILES]
O=C1CC(C2=C(Cl)C(Cl)=C(Cl)C(Cl)=C21)=O |
| Hazard Information | Back Directory | [Description]
TCID (30675-13-9) inhibits ubiquitin C-terminal hydrolase L3 (UCH-L3). IC50=0.6 μM, 125-fold selective over UCH-L1, IC50=75 μM. Cell permeable. | [Uses]
Novel inhibitor of ubiquitin C-terminal hydrolase L3 (IC50 = 0.6μM). Displays 125-fold greater selectivity over UCH-L1 (IC50 = 75μM). | [storage]
Store at -20°C | [References]
1) Love et al. (2007), Mechanisms, biology and inhibitors of deubiquitinating enzymes; Nat. Chem. Biol., 3 697
2) Mtango et al. (2012), Essential role of ubiquitin C-terminal hydrolases UCHL1 and UCHL3 in mammalian oocyte maturation; J. Cell Physiol., 227 2022 |
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| Company Name: |
Modachem Shanghai Co., Ltd
|
| Telephone: |
+86 (0)21 51320687 51371369 1744605818 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList16334/0_EN.htm |
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