| Identification | Back Directory | [Name]
H-Pro-Phe-Cys-Asn-Ala-Phe-Thr-Gly-Cys-OH (Cys3-Cys9) | [CAS]
309247-84-5 | [Synonyms]
CRUSTACEAN CARDIOACTIVE PEPTIDE, CCAP
H-Pro-Phe-Cys-Asn-Ala-Phe-Thr-Gly-Cys-OH (Cys3-Cys9)
PRO-PHE-CYS-ASN-ALA-PHE-THR-GLY-CYS(DISULFIDE BRIDGE CYS3-CYS9)
L-Cysteine, L-prolyl-L-phenylalanyl-L-cysteinyl-L-asparaginyl-L-alanyl-L-phenylalanyl-L-threonylglycyl- | [Molecular Formula]
C42H58N10O12S2 | [MDL Number]
MFCD00076622 | [MOL File]
309247-84-5.mol | [Molecular Weight]
959.1 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 50 mg/mL (52.13 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
Solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Crustacean cardioactive peptide, free acid is a highly conserved, amidated cyclic nonapeptide, first isolated from the pericardial organs of the shore crab Carcinus maenas, where it has a role in regulating heartbeat; Crustacean cardioactive peptide, free acid also modulates the neuronal activity in other arthropods. | [in vivo]
CCAP, FMRFamide and SALDKNFMRFamide increase the mosquito antennal accessory pulsatile organ (APO) and heart contraction rates, increase hemolymph flow velocity in the antennal space[1]. | [References]
[1] Suggs JM, et al. CCAP and FMRFamide-like peptides accelerate the contraction rate of the antennal accessory pulsatile organs (auxiliary hearts) of mosquitoes. J Exp Biol. 2016 Aug 1;219(Pt 15):2388-95. DOI:10.1242/jeb.141655
[2] Moris-Sanz M, et al. The study of the Bithorax-complex genes in patterning CCAP neurons reveals a temporal control of neuronal differentiation by Abd-B. Biol Open. 2015 Aug 14;4(9):1132-42. DOI:10.1242/bio.012872 |
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Ontores Biotech
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www.ontoresinc.cn |
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