| Identification | Back Directory | [Name]
Sideroxylin | [CAS]
3122-87-0 | [Synonyms]
Sideroxylin
Sideroxyline
5,4'-dihydroxy-7-methoxy-6,8-dimethylflavone
4',5-Dihydroxy-7-methoxy-6,8-dimethylflavone
4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-6,8-dimethyl- | [Molecular Formula]
C18H16O5 | [MDL Number]
MFCD20260427 | [MOL File]
3122-87-0.mol | [Molecular Weight]
312.32 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder | [color ]
Yellow |
| Hazard Information | Back Directory | [Uses]
Sideroxylin is a C-methylated flavone isolated from Callistemon lanceolatus and exerts antimicrobial activity against Staphylococcus aureus. Sideroxylin inhibits ovarian cancer cell proliferation and induces apoptosis, causing DNA fragmentation, depolarization of the mitochondrial membrane, the generation of reactive oxygen species (ROS)[1]. | [Definition]
ChEBI: Sideroxylin is a monomethoxyflavone that is flavone substituted by a methoxy group at position 7, hydroxy groups at positions 5 and 4' and methyl groups at positions 6 and 8. It has been isolated from Hydrastis canadensis and Eucalyptus species. It has a role as a plant metabolite. It is a dihydroxyflavone and a monomethoxyflavone. It is functionally related to a flavone. | [target]
Antifection | [storage]
Store at -20°C | [References]
[1] Sunwoo Park, et al. Sideroxylin (Callistemon Lanceolatus) Suppressed Cell Proliferation and Increased Apoptosis in Ovarian Cancer Cells Accompanied by Mitochondrial Dysfunction, the Generation of Reactive Oxygen Species, and an Increase of Lipid Peroxidat DOI:10.1002/jcp.26540 |
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