| Identification | Back Directory | [Name]
M2I-1 | [CAS]
312271-03-7 | [Synonyms]
M2I-1
M2I1;M2I 1;M2I-1
Mad2 inhibitor-1
Mad2 inhibitor-1 (M2I-1)
5-[[4-[bis(2-methylpropyl)amino]-3-nitrophenyl]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione
4,6(1H,5H)-Pyrimidinedione, 5-[[4-[bis(2-methylpropyl)amino]-3-nitrophenyl]methylene]dihydro-2-thioxo- | [Molecular Formula]
C19H24N4O4S | [MDL Number]
MFCD00469459 | [MOL File]
312271-03-7.mol | [Molecular Weight]
404.48 |
| Chemical Properties | Back Directory | [density ]
1.30±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: slightly soluble | [form ]
A crystalline solid | [pka]
4.79±0.20(Predicted) | [color ]
Yellow to orange |
| Hazard Information | Back Directory | [Uses]
M2I-1 is a Mad2 inhibitor targeting the binding of Mad2 to Cdc20, an essential protein-protein interaction (PPI) within the spindle assembly checkpoint (SAC)[1]. | [Biological Activity]
Cell permeable: yes''Primary Target
Mad2''Reversible: yes | [storage]
Store at -20°C | [References]
[1] Johanna Kastl et al. Mad2 Inhibitor-1 (M2I-1): A Small Molecule Protein-Protein Interaction Inhibitor Targeting the Mitotic Spindle Assembly Checkpoint. ACS Chem. Biol., 2015, 10 (7), pp 1661-1666. DOI:10.1021/acschembio.5b00121 |
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