| Identification | Back Directory | [Name]
Reversan | [CAS]
313397-13-6 | [Synonyms]
Reversan
CBLC4H10
N-[3-(4-morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide
Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-(4-morpholinyl)propyl]-5,7-diphenyl-
5,7-Diphenyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (3-morpholin-4-yl-propyl)-amide
ReversanQ: What is
Reversan Q: What is the CAS Number of
Reversan Q: What is the storage condition of
Reversan Q: What are the applications of
Reversan | [Molecular Formula]
C26H27N5O2 | [MDL Number]
MFCD01528184 | [MOL File]
313397-13-6.mol | [Molecular Weight]
441.52 |
| Chemical Properties | Back Directory | [Melting point ]
176-180°C | [density ]
1.26±0.1 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
DMSO: ≥8mg/mL at ~60°C | [form ]
powder | [pka]
11.33±0.46(Predicted) | [color ]
faint yellow to yellow | [InChI]
1S/C26H27N5O2/c32-26(27-12-7-13-30-14-16-33-17-15-30)22-19-28-31-24(21-10-5-2-6-11-21)18-23(29-25(22)31)20-8-3-1-4-9-20/h1-6,8-11,18-19H,7,12-17H2,(H,27,32) | [InChIKey]
JTRXWCLQFAZHGP-UHFFFAOYSA-N | [SMILES]
O=C(NCCCN1CCOCC1)c2cnn3c(cc(nc23)-c4ccccc4)-c5ccccc5 |
| Hazard Information | Back Directory | [Uses]
Reversan represents a new class of nontoxic MRP1 inhibitor, which may be clinically useful for the treatment of neuroblastoma. | [Biological Activity]
Selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin , vincristine and etoposide by 3.8-, 14.6- and 11.6-fold respectively. Increases the efficacy of vincristine and etoposide in murine models of neuroblastoma in vivo . Displays at activity on MRP2, MRP3, MRP5 and MRP5 transporters. | [storage]
Store at -20°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
|