| Identification | Back Directory | [Name]
7-CHLORO-4-QUINAZOLINOL | [CAS]
31374-18-2 | [Synonyms]
7-CHLOROQUINAZOLIN-4-OL
7-CHLORO-4-QUINAZOLINOL
7-Chloroquinazolin-4-one
7-Chloro-4(3H)-quinazolone
7-Chloro-3H-quizolin-4-one
7-CHOROQUINAZOLIN-4(3H)-ONE
7-Chloroquinazolin-4(1H)-one
7-chloro-4(3H)-quinazolinone
7-Chloroquinazolin-4(3H)-one
7-chloro-1H-quinazolin-4-one
7-CHLORO-4(1H)-QUINAZOLINONE
7-CHLORO-4-HYDROXYQUINAZOLINE
4(3H)-Quinazolinone, 7-chloro-
7-Chloro-4(3H-quinazolin-4-one
Benzenesulfonylchloride,9-ethoxy-
7-Chloro-3H-quinazolin-4-one
7-CHLORO-4-QUINAZOLINOL###31374-18-2
7-chloro-1,4-dihydroquinazolin-4-one
7-Chloro-4-Hydroxyquinazoline(WX636185)
Cyclopropanamine,1-ethyl-,hydrochloride(1:5) | [EINECS(EC#)]
207-219-2 | [Molecular Formula]
C8H5ClN2O | [MDL Number]
MFCD00115130 | [MOL File]
31374-18-2.mol | [Molecular Weight]
180.59 |
| Chemical Properties | Back Directory | [Melting point ]
251-253 °C | [Boiling point ]
331.7±44.0 °C(Predicted) | [density ]
1.50±0.1 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [pka]
0.36±0.20(Predicted) | [Appearance]
Off-white to light brown Solid | [InChI]
InChI=1S/C8H5ClN2O/c9-5-1-2-6-7(3-5)10-4-11-8(6)12/h1-4H,(H,10,11,12) | [InChIKey]
PMLONMIODRHERC-UHFFFAOYSA-N | [SMILES]
N1C2=C(C=CC(Cl)=C2)C(=O)NC=1 |
| Hazard Information | Back Directory | [Synthesis Reference(s)]
Journal of the American Chemical Society, 68, p. 1305, 1946 DOI: 10.1021/ja01211a058 | [Synthesis]
The general procedure for the synthesis of 7-chloro-4(3H)-quinazolinone from formamidine acetate and 2-amino-4-chlorobenzoic acid was as follows: 10 g of 2-amino-4-chlorobenzoic acid (BB1) and 8 g of formamidine acetate (1.3 eq.) were added to a 100 ml eggplant flask and mixed thoroughly. The mixture was placed in a microwave reactor and reacted at 60% power for 4 min. After completion of the reaction, it was cooled to room temperature, 30 ml of water was added, stirred and the solid product was collected by filtration. The resulting product was 7-chloro-4(3H)-quinazolinone (BB2) in a yield of 10 g with 95% yield. | [References]
[1] Patent: CN103570738, 2016, B. Location in patent: Paragraph 0303; 0304; 0306
[2] Patent: CN103382182, 2016, B. Location in patent: Paragraph 0272-0275
[3] Patent: WO2012/88712, 2012, A1. Location in patent: Page/Page column 16
[4] MedChemComm, 2015, vol. 6, # 1, p. 222 - 229 |
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