315228-79-6

140-89-6

33348-34-4

315228-79-6

The general procedure for the synthesis of 2-mercaptobenzothiazole-6-carbonitrile from potassium ethylxanthate and 4-amino-3-iodobenzonitrile was as follows: 4-amino-3-iodobenzonitrile (0.6 mmol), potassium ethylxanthate (1.8 mmol), FeF3 (0.06 mmol), 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl ( 0.03 mmol) and DMF (4 mL). The reaction vessel was replaced three times with argon and sealed. Subsequently, the mixture was placed in an oil bath at 110 °C and the reaction was electromagnetically stirred for 3-21 hours. The reaction process was monitored by silica gel thin layer chromatography (TLC). After completion of the reaction, the reaction mixture was cooled to room temperature, 4 mL of 3 mol/L hydrochloric acid solution was added and stirred for 30 min. The reaction mixture was extracted with ethyl acetate (3 x 20 mL). The organic phases were combined, dried with anhydrous sodium sulfate, and finally purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate) to obtain the target product 2-mercaptobenzothiazole-6-carbonitrile.