| Identification | Back Directory | [Name]
POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT | [CAS]
31852-29-6 | [Synonyms]
PolyI：C-K
Poly I：C PotassiuM Salt
POLY[I] POLY[C] POTASSIUM SALT
polyinosinic-polycytidylic acid*potassium
polyinosinic acid/ polycytidylic potassium
Kanamycin-polyI-polyC potassium salt complex
POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT
Polyinosinic acid . Polycytidylic acid potassium salt
Inosinic acid-cytidylic acid polymer complex potassium salt
5'-Cytidylic acid polymers complex with 5'-inosinic acid polymers potassium salt
5'-Cytidylic acid homopolymer complex with 5'-inosinic acid homopolyme potassium salt
5'-Inosinic acid homopolymer complex with 5'-cytidylic acid homopolymer potassium salt
5'-Inosinic acid,homopolymer, complex with 5'-cytidylic acid homopolymer (1:1), potassium salt | [Molecular Formula]
C19H27KN7O16P2* | [MDL Number]
MFCD00131983 | [MOL File]
31852-29-6.mol | [Molecular Weight]
710.501 |
| Hazard Information | Back Directory | [Uses]
(Polyinosinic-polycytidylic acid potassium salt) TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. Polyinosinic–polycytidylic acid (Poly(I) • Poly(C)) is a double-stranded homopolymer used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.
| [Uses]
Polyinosinic-polycytidylic Acid Potassium Salt triggers apoptosis in some cancer cells. | [Biological Activity]
Transfection of Poly (I:C) into NIT-1 cells has been used as a model of intracellular dsRNA-induced β cell apoptosis. Eighteen hours post transfection45% of the cells were apoptotic with an increase in NF-kBp50/p65 nuclear translocationand cleavage of caspases 3 and 8as well as transcriptional induction of caspase 12FasIL-15and the TNF receptor-associated ligand (TRAIL). It has been suggested th at Poly(I:C) is one of the most appropriate generators of stable mature dendritic cells (DC). These mature DC might generate in vivo effective immune responses after injection due to their ability to secrete bioactive IL-12 after CD40 ligation. Poly (I:C) was used as a potent adjuvant to enhance the specific anti-tumor immune responses against a peptide-based vaccine. | [in vivo]
Polyinosinic-polycytidylic acid potassium (50 μg; i.v.; on days 3, 6, and 9 after tumor inoculation) shows antitumor activity in NOD/SCID immunodeficient mice[1]. | Animal Model: | NOD/SCID immunodeficient mice (1205Lu cells)[1] | | Dosage: | 50 μg | | Administration: | I.v.; on days 3, 6, and 9 after tumor inoculation | | Result: | Reduced the size of metastases and the total amount of tumor tissue, and the level of human DNA was 50% lower in mice. |
| [IC 50]
TLR3 |
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