| Identification | Back Directory | [Name]
4-CHLOROBENZO[F]ISOQUINOLINE | [CAS]
32081-28-0 | [Synonyms]
CBIQ
CBIQ >=98% (HPLC), solid
4-CHLOROBENZO[F]ISOQUINOLINE
Benz[f]isoquinoline, 4-chloro- | [Molecular Formula]
C13H8ClN | [MDL Number]
MFCD02179769 | [MOL File]
32081-28-0.mol | [Molecular Weight]
213.66 |
| Chemical Properties | Back Directory | [Boiling point ]
400.3±18.0 °C(Predicted) | [density ]
1.312±0.06 g/cm3(Predicted) | [solubility ]
DMSO: soluble15mg/mL | [form ]
solid | [pka]
3.21±0.30(Predicted) | [color ]
off-white | [InChI]
1S/C13H8ClN/c14-13-12-6-5-9-3-1-2-4-10(9)11(12)7-8-15-13/h1-8H | [InChIKey]
SHQLTRRYZVBEMR-UHFFFAOYSA-N | [SMILES]
Clc1nccc2c1ccc3ccccc23 |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25-37/38-41 | [Safety Statements ]
26-39-45 | [RIDADR ]
UN 2811 6.1 / PGIII | [WGK Germany ]
3 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Biological Activity]
CBIQ is an activator of the cystic fibrosis transmembrane conductance regulator (CFTR) and the intermediate-conductance calcium-sensitive K+ channel (KCNN4). CBIQ is a novel tool for a new ion channel; first activator of ΔF508 CFTR the mutant form of CFTR chloride channel present in 75% of cystic fibrosis patients. Other benzoquinolines act at the normal CFTR but not at ΔF508 CFTR. CBIQ also activates KCNN4which hyperpolarizes airway epithelial cells to promote anion fluxa further benefit in cystic fibrosis. |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|