| Identification | Back Directory | [Name]
EO 1428 | [CAS]
321351-00-2 | [Synonyms]
EO 1428
p38 MAPK Inhibitor VIII
p38 MAP Kinase Inhibitor VIII
(2-Methylphenyl)-[4-[(2-amino-4-bromophenyl)amino]-2-chlorophenyl]methanone
Methanone, [4-[(2-amino-4-bromophenyl)amino]-2-chlorophenyl](2-methylphenyl)- | [Molecular Formula]
C20H16BrClN2O | [MDL Number]
MFCD11100188 | [MOL File]
321351-00-2.mol | [Molecular Weight]
415.71 |
| Hazard Information | Back Directory | [Uses]
EO 1428 is a p38 MAP kinase inhibitor with high antiinflammatory activity. | [Definition]
ChEBI: [4-(2-amino-4-bromoanilino)-2-chlorophenyl]-(2-methylphenyl)methanone is a member of benzophenones. | [Biological Activity]
Selective inhibitor of p38 α and p38 β 2 that displays no activity at p38 γ , p38 δ , ERK1/2 and JNK1. Inhibits production of inflammatory cytokines including IL-8, TNF- α , IL-6, IL-1 β and IL-10 (IC 50 values are 4, 5, 17, 30 and 74 nM respectively). Displays anti-inflammatory activity in murine models of acute and chronic dermatitis. | [storage]
Store at -20°C |
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| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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