| Identification | More | [Name]
1-TRIMETHYLSILYLMETHANOL | [CAS]
3219-63-4 | [Synonyms]
1-TRIMETHYLSILYLMETHANOL
(HYDROXYMETHYL)TRIMETHYLSILANE
TRIMETHYLHYDROXYMETHYLSILANE
(TRIMETHYLSILYL)METHANOL
(hydroxymethyl)trimethyl-silan
(trimethylsilyl)-methano
Methanol, (trimethylsilyl)-
Silane, (hydroxymethyl)trimethyl-
1-TRIMETHYLSILYLMETHANOL, 98+% | [EINECS(EC#)]
221-746-5 | [Molecular Formula]
C4H12OSi | [MDL Number]
MFCD00004596 | [Molecular Weight]
104.22 | [MOL File]
3219-63-4.mol |
| Chemical Properties | Back Directory | [Melting point ]
<0°C | [Boiling point ]
120-122 °C754 mm Hg(lit.) | [density ]
0.826 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.419(lit.)
| [Fp ]
88 °F
| [storage temp. ]
2-8°C
| [form ]
clear liquid | [pka]
15.92±0.10(Predicted) | [color ]
Colorless to Almost colorless | [Specific Gravity]
0.827 | [Water Solubility ]
Fully miscible in water. | [Hydrolytic Sensitivity]
1: no significant reaction with aqueous systems | [BRN ]
1731486 | [InChI]
1S/C4H12OSi/c1-6(2,3)4-5/h5H,4H2,1-3H3 | [InChIKey]
ZQKNBDOVPOZPLY-UHFFFAOYSA-N | [SMILES]
C[Si](C)(C)CO | [CAS DataBase Reference]
3219-63-4(CAS DataBase Reference) | [EPA Substance Registry System]
Methanol, (trimethylsilyl)- (3219-63-4) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS02,GHS07 | [Signal word ]
Warning | [Hazard statements ]
H226-H315-H319-H335 | [Precautionary statements ]
P261-P305+P351+P338-P210-P240-P241-P280a-P303+P361+P353-P501a | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 1987 3/PG 3
| [WGK Germany ]
3
| [RTECS ]
PC4100000
| [TSCA ]
Yes | [HS Code ]
2931.90.9010 | [HazardClass ]
3 | [PackingGroup ]
III | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Uses]
1-Trimethylsilylmethanol is used as nucleophile to resolve the racemate obtained from enantioselective esterification of naproxen (2-(6-methoxy-2-naphthyl) propionic acid) by lipases. It was also used as a nucleophilic hydroxymethylation agent. | [Purification Methods]
If the NMR indicates impurities (should have only two signals), then dissolve it in Et2O, shake this with aqueous 5N NaOH, M H2SO4, saturated aqueous NaCl, dry (MgSO4) and distil it using an efficient column at atmospheric pressure. The 3,5-dinitrobenzoate has m 70-70.5o (from 95% EtOH). [Huang & Wang Acta Chem Sin 23 291 1957, cf. Chem Abstr 52 19911 1958, Speier et al. J Am Chem Soc 81 1844 1959 and Speier et al. J Am Chem Soc 70 1117 1948, Beilstein 4 III 1844, 4 IV 2876.] |
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