| Identification | Back Directory | [Name]
Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide | [CAS]
325970-71-6 | [Synonyms]
L67 >=98% (HPLC)
DNA LIGASE INHIBITOR; L-67; L 67
Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide | [Molecular Formula]
C16H14Br2N4O4 | [MDL Number]
MFCD00363966 | [MOL File]
325970-71-6.mol | [Molecular Weight]
486.11 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:21.5(Max Conc. mg/mL);44.23(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);20.57(Max Conc. mM)
Water:1.0(Max Conc. mg/mL);2.06(Max Conc. mM) | [form ]
A crystalline solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
L67 is a competitive inhibitor of DNA ligases I and III (IC50s = 10 and 10 μM for human DNA ligase I and human ligase IIIβ). It blocks DNA binding (Ki = 10 μM), increasing the cytotoxicity of DNA-damaging agents. It also inhibits mitochondrial DNA ligase IIIα and induces the production of reactive oxygen species (ROS) and apoptosis in cancerous, but not non-malignant, cells. It does not inhibit DNA ligase IV or T4 DNA ligase at concentrations up to 100 μM. | [Uses]
L 67 is used in the identification and validation of human DNA ligase inhibitors using computer-aided grug design. | [IC 50]
DNA ligases I: 10 μM (IC50); DNA ligases III: 10 μM (IC50); Caspase-1 | [References]
[1] XI CHEN. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair.[J]. Cancer research, 2008: 3169-3177. DOI: 10.1158/0008-5472.can-07-6636
[2] ANNAHITA SALLMYR. Inhibiting Mitochondrial DNA Ligase IIIα Activates Caspase 1-Dependent Apoptosis in Cancer Cells.[J]. ACS Chemical Health & Safety, 2016: 5431-5441. DOI: 10.1158/0008-5472.can-15-3243 |
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