| Identification | Back Directory | [Name]
4-Thiazolidinone, 2-phenyl-3-(2-pyridinylmethyl)- | [CAS]
326879-46-3 | [Synonyms]
NMT-IN-1
WAY-606529
2-Phenyl-3-(pyridin-2-ylmethyl)thiazolidin-4-one
4-Thiazolidinone, 2-phenyl-3-(2-pyridinylmethyl)- | [Molecular Formula]
C15H14N2OS | [MOL File]
326879-46-3.mol | [Molecular Weight]
270.35 |
| Chemical Properties | Back Directory | [Boiling point ]
505.6±50.0 °C(Predicted) | [density ]
1.278±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.51±0.12(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
NMT-IN-1 (compound 9) is a potent N-Myristoyltransferase (NMT) Inhibitor with IC50 values of 31 and 66 μM for TbNMT and hNMT, respectively. NMT-IN-1 can be used in research of african trypanosomiasis[1]. | [References]
[1] Spinks D, et, al. Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode. ChemMedChem. 2015 Nov;10(11):1821-36. DOI:10.1002/cmdc.201500301 |
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