| Identification | Back Directory | [Name]
VLX600 | [CAS]
327031-55-0 | [Synonyms]
Ethanone, 1-(2-pyridinyl)-, 2-(6-methyl-5H-1,2,4-triazino[5,6-b]indol-3-yl)hydrazone
6-methyl-N-[(E)-1-pyridin-2-ylethylideneamino]-5H-[1,2,4]triazino[5,6-b]indol-3-amine
6-methyl-3-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)-5H-[1,2,4]triazino[5,6-b]indole | [Molecular Formula]
C17H15N7 | [MDL Number]
MFCD01305422 | [MOL File]
327031-55-0.mol | [Molecular Weight]
317.36 |
| Chemical Properties | Back Directory | [Boiling point ]
590.9±58.0 °C(Predicted) | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C,unstable in solution, ready to use. | [solubility ]
≤1mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide | [form ]
crystalline solid | [pka]
7.53±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
VLX600 is a compound that shows selective cytotoxicity against quiescent cancer cells (IC50 = 1-10 μM) with selectivity for malignant cells. It induces necrosis in non-proliferating quiescent core cells in multicellular spheroids (MCs) formed from HCT116 colon cancer cells. VLX600 induces the expression of genes associated with hypoxia, glycolysis, and p53 signaling, stimulates autophagy, and triggers mitochondrial dysfunction in MCs. It displays antitumor activity against colon cancer xenografts with minimal systemic toxicity in mice. | [Uses]
VLX600 is a compound showing cytotoxicity against cancer cells. Selective towards malignant cells and necrosis inductor in colon cancer cells. | [in vivo]
VLX600 (16 mg/kg; i.v.; every third day for 16 days) shows anti-tumor activity in human tumor xenografts[2]. | Animal Model: | NMRI nu/nu mice (HCT116 and HT29 colon cancer xenografts)[2] | | Dosage: | 16?mg/kg | | Administration: | Intravenously; every third day for 16 days | | Result: | Anti-tumor activity was observed in both HCT116 and HT29 colon cancer xenografts.
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| [References]
zhang x, frykns m, hernlund e, et al. induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments. nat commun. 2014;5:3295. |
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| Company Name: |
Energy Chemical
|
| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Bide Pharmatech Ltd.
|
| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
| Company Name: |
InvivoChem
|
| Telephone: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|