| Identification | Back Directory | [Name]
6-[4-(diethylamino)-3-nitrophenyl]-5-methyl-2,3,4,5-tetrahydropyridazin-3-one | [CAS]
328104-79-6 | [Synonyms]
DNMDP
3(2H)-Pyridazinone, 6-[4-(diethylamino)-3-nitrophenyl]-4,5-dihydro-5-methyl-
6-[4-(diethylamino)-3-nitrophenyl]-5-methyl-2,3,4,5-tetrahydropyridazin-3-one | [Molecular Formula]
C15H20N4O3 | [MDL Number]
MFCD01829240 | [MOL File]
328104-79-6.mol | [Molecular Weight]
304.34 |
| Chemical Properties | Back Directory | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 50 mg/mL (164.29 mM; Need ultrasonic) | [form ]
Solid | [pka]
13.30±0.60(Predicted) | [color ]
Orange to red |
| Hazard Information | Back Directory | [Biological Activity]
DNMDP, a phosphodiesterase 3A (PDE3A) inhibitor, is a potent and selective cancer cell cytotoxic agent. DNMDP binding to PDE3A promotes an interaction between PDE3A and Schlafen 12 (SLFN12). DNMDP shows clear cell-selective cytotoxicity[1].
DNMDP (0-1000 μM; 48 hours) shows clear cell-selective cytotoxicity[1]. HeLa cells undergo apoptosis upon DNMDP treatment, indicates by caspase activity detected by a caspase-sensitive luciferase assay and by poly ADP ribose polymerase (PARP) cleavage. At a concentration of 100 nM, DNMDP specifically inhibits both PDE3A and PDE3B, weakly inhibits PDE10, and had little or no detectable effect on other phosphodiesterases[1]. | [References]
[1]. de Waal L, et al. Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics. Nat Chem Biol. 2016 Feb;12(2):102-8. |
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