| Identification | Back Directory | [Name]
inS3-54A18 | [CAS]
328998-53-4 | [Synonyms]
inS3-54A18
2H-Pyrrol-2-one, 3-[(4-chlorophenyl)methylene]-1,3-dihydro-1-(4-hydroxyphenyl)-5-phenyl- | [Molecular Formula]
C23H16ClNO2 | [MOL File]
328998-53-4.mol | [Molecular Weight]
373.83 |
| Chemical Properties | Back Directory | [Boiling point ]
630.5±55.0 °C(Predicted) | [density ]
1.363±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 150 mg/mL (401.25 mM) | [form ]
Solid | [pka]
10.05±0.30(Predicted) | [color ]
Yellow to orange |
| Hazard Information | Back Directory | [Uses]
inS3-54A18 is a potent STAT3 inhibitor, with anti-cancer properties. | [in vivo]
inS3-54A18 (200?mg/kg, p.o.) inhibits tumor growth, metastasis and expression of STAT3 target genes in a mouse xenograft model of A549 cells[1]. | [IC 50]
STAT3 | [storage]
Store at -20°C | [References]
[1] Huang W, et al. Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. Oncogene. 2016 Feb 11;35(6):783-92. DOI:10.1038/onc.2015.215
[2] Huang W, et al. Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. Oncogene. 2016 Feb 11;35(6):783-92 |
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InvivoChem
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