| Identification | More | [Name]
p-Anisohydrazide | [CAS]
3290-99-1 | [Synonyms]
4-METHOXYBENZENE-1-CARBOHYDRAZIDE
4-METHOXYBENZHYDRAZIDE
4-METHOXYBENZOHYDRAZIDE
4-METHOXY-BENZOIC ACID HYDRAZIDE
4-METHOXYBENZOYLHYDRAZINE
AKOS 92185
AKOS BBS-00004504
LABOTEST-BB LT00025103
P-ANISIC HYDRAZIDE
p-anisohydrazide
P-ANISOYLHYDRAZINE
P-METHOXY BENZHYDRAZIDE
(p-methoxybenzoyl)hydrazine
4-methoxybenzoylhydrazide
4-methoxybenzoyl-hydrazin
anisicacidhydrazide
anisichydrazide
anisoylhydrazine
p-anisicacid,hydrazide
p-methoxybenzoicacidhydrazide | [EINECS(EC#)]
221-952-5 | [Molecular Formula]
C8H10N2O2 | [MDL Number]
MFCD00017073 | [Molecular Weight]
166.18 | [MOL File]
3290-99-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
136-140 °C(lit.) | [Boiling point ]
294.38°C (rough estimate) | [density ]
1.2265 (rough estimate) | [refractive index ]
1.6180 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
powder to crystal | [pka]
12.65±0.10(Predicted) | [color ]
White to Orange to Green | [Water Solubility ]
Slightly soluble in water. | [BRN ]
389017 | [InChIKey]
REKQLYUAUXYJSZ-UHFFFAOYSA-N | [CAS DataBase Reference]
3290-99-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [RTECS ]
BZ4800000
| [HazardClass ]
IRRITANT | [HS Code ]
2928009090 | [Safety Profile]
Poison by intravenous
route. Questionable carcinogen with
experimental neoplastigenic data. When heated to decomposition it emits toxic
fumes of Nox. | [Toxicity]
LD50 ivn-mus: 178 mg/kg CSLNX* NX#00894 |
| Hazard Information | Back Directory | [Uses]
4-Methoxybenzhydrazide may be used to synthesize:
- N′-[(E)-5-bromo-2-hydroxy-3-methoxybenzylidene]-4-methoxybenzohydrazide monohydrate
- 2,5-bis(4-methoxyphenyl)-1,3,4-oxadiazole
- hydrazone ligands, which readily forms ruthenium(II) hydrazone complexes via reaction with [RuHCl(CO)(PPh3)3]
| [Uses]
4-Methoxybenzhydrazide is used as pharmaceutical intermediates and it is also involved in a variety of organic synthesis. | [Synthesis Reference(s)]
Journal of Medicinal Chemistry, 27, p. 1565, 1984 DOI: 10.1021/jm00378a007 | [Synthesis]
4-Methoxybenzoic acid hydrazide was synthesized according to literature [22]. A mixture of methyl 4-methoxybenzoate (1.66 g, 10 mmol) with 80% hydrazine hydrate (3.6 mL, 60 mmol) in anhydrous ethanol (20 mL) was heated and refluxed for 6 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure to give a white precipitate. The crude product was recrystallized from anhydrous ethanol to give 4-methoxybenzohydrazide as colorless needle-like crystals. Yield 96%, melting point 138-139°C (literature values in accordance). | [References]
[1] Journal of the American Chemical Society, 2013, vol. 135, # 15, p. 5656 - 5668
[2] Journal of the Chilean Chemical Society, 2012, vol. 57, # 4, p. 1492 - 1496
[3] Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2017, vol. 174, p. 272 - 278
[4] European Journal of Medicinal Chemistry, 1985, vol. 20, # 3, p. 257 - 266
[5] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 16, p. 4842 - 4850 |
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