| Identification | More | [Name]
1-Tritylimidazole-4-carboxaldehyde | [CAS]
33016-47-6 | [Synonyms]
1-(TRIPHENYLMETHYL)IMIDAZOLE-4-CARBOXALDEHYDE
1-TRITYL-1H-IMIDAZOLE-4-CARBOXALDEHYDE
1-TRITYLIMIDAZOLE-4-CARBOXALDEHYDE
4-FORMYL-1-TRITYLIMIDAZOLE
AKOS 215-50
RARECHEM AN KA 0027
1-TRITYL-IMDAZOLE-4-CARBOXADEHYDE
1-Trityl-1H-imidazole-4-carboxaldehyde 98%
1-Triphenylmethyl-4-imidazolecarboxaldehyde
1-TRITYLIMIDAZOLE-4-CARBOXALDEHYDE, 97+%
1-TRIPHENYLMETHYL-IMDAZOLE-4-CARBOXADEHYDE
1-Trityl-1H-imidazole-4-carbaldehyde | [EINECS(EC#)]
620-447-0 | [Molecular Formula]
C23H18N2O | [MDL Number]
MFCD02179554 | [Molecular Weight]
338.4 | [MOL File]
33016-47-6.mol |
| Chemical Properties | Back Directory | [Melting point ]
180-190°C | [Boiling point ]
502.8±45.0 °C(Predicted) | [density ]
1.10±0.1 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Acetonitrile (Slightly), Methanol (Slightly) | [form ]
Crystalline Powder | [pka]
2.28±0.61(Predicted) | [color ]
White to brown | [InChI]
InChI=1S/C23H18N2O/c26-17-22-16-25(18-24-22)23(19-10-4-1-5-11-19,20-12-6-2-7-13-20)21-14-8-3-9-15-21/h1-18H | [InChIKey]
YQYLLBSWWRWWAY-UHFFFAOYSA-N | [SMILES]
C1N(C(C2=CC=CC=C2)(C2=CC=CC=C2)C2=CC=CC=C2)C=C(C=O)N=1 | [CAS DataBase Reference]
33016-47-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [Hazard Note ]
Irritant | [HS Code ]
29332900 |
| Hazard Information | Back Directory | [Uses]
1-Tritylimidazole-4-carboxaldehyde(33016-47-6) is used in the synthesis of histamine and girolline
| [Synthesis]
Example 33: Synthesis of 1-trityl-1H-imidazole-4-carbaldehyde
4-Imidazolecarboxaldehyde (30.0 g, 0.30 mol) was dissolved in DMF (200 mL) and triethylamine (70 mL, 0.375 mol) was added slowly under cooling in an ice bath. Triphenylchloromethane (105 g, 0.375 mol) was then added in batches and the reaction mixture was stirred at room temperature overnight. After completion of the reaction, the solvent was removed by vacuum evaporation and the residue was washed with anhydrous ether (4 x 50 mL) and dried to give a yellow solid 1-tritylimidazole-4-carboxaldehyde (100 g, 100%). | [References]
[1] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 23, p. 7993 - 8002
[2] Patent: WO2008/4096, 2008, A1. Location in patent: Page/Page column 79
[3] Journal of Medicinal Chemistry, 2002, vol. 45, # 1, p. 177 - 188
[4] European Journal of Organic Chemistry, 2015, vol. 2015, # 18, p. 3957 - 3962
[5] Patent: US2004/122018, 2004, A1. Location in patent: Page 317 |
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