| Identification | Back Directory | [Name]
5-TRANS U-44069 | [CAS]
330796-57-1 | [Synonyms]
5-TRANS U-44069
DJKDIKIDYDXHDD-YTQMDITASA-N
9,11-DIDEOXY-9ALPHA, 11ALPHA-EPOXYMETHANO-PROSTA-5E,13E-DIEN-1-OIC ACID | [Molecular Formula]
C21H34O4 | [MDL Number]
MFCD00077407 | [MOL File]
330796-57-1.mol | [Molecular Weight]
350.49 |
| Chemical Properties | Back Directory | [Boiling point ]
519.7±35.0 °C(Predicted) | [density ]
1.092±0.06 g/cm3(Predicted) | [solubility ]
DMF: >100 mg/ml (from U-46619); DMSO: >100 mg/ml (from U-46619); Ethanol: >100 mg/ml (from U-46619); PBS pH 7.2: >2 mg/ml (from U-46619) | [pka]
4.76±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
5-trans U-44069 is the trans isomer of the thromboxane receptor agonist U-44069 . It inhibits microsomal prostaglandin E2 synthase (mPGES) when used at a concentration of 10 μM.1 | [Uses]
5-trans U-44069 is the trans isomer of the thromboxane receptor agonist U-44069 (HY-121825). 5-trans U-44069 inhibits prostaglandin E2 synthase activity[1]. | [References]
1. Quraishi, O., Mancini, J.A., and Riendeau, D. Inhibition of inducible prostaglandin E2 synthase by 15-deoxy-Δ12,14-prostaglandin J2 and polyunsaturated fatty acids Biochem. Pharmacol. 63(6),1183-1189(2002). |
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