| Identification | More | [Name]
Benzidamine hydrochloride | [CAS]
132-69-4 | [Synonyms]
1-BENZYL-3-[3-(DIMETHYLAMINO)-PROPOXY]-1H-INDAZOLE HYDROCHLORIDE
BENZYDAMINE HCL
BENZYDAMINE HYDROCHLORIDE
LABOTEST-BB LT00771795
1-benzyl-3-(3-(dimethylamino)propoxy)-1h-indazolmonohydrochloride
1-benzyl-3-gamma-dimethylaminopropoxy-1h-indazolehydrochloride
af864
benalgin
benzidaminehydrochloride
benzindaminehydrochloride
benzyrin
difflam
dorinamin
enzamin
epirotin
imotryl
indolin
n,n-dimethyl-3-((1-(phenylmethyl)-1h-indazol-3-yl)oxy)-1-propanaminhydro
ririlim
riripen | [EINECS(EC#)]
205-076-0 | [Molecular Formula]
C14H12ClNO2 | [MDL Number]
MFCD00078957 | [Molecular Weight]
261.7 | [MOL File]
132-69-4.mol |
| Chemical Properties | Back Directory | [Melting point ]
147-153°C | [storage temp. ]
2-8°C
| [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
neat | [color ]
White to Off-White | [Water Solubility ]
Soluble in water, ethanol, chloroform, n-butanol or DMSO
/n | [Merck ]
14,1122 | [InChI]
InChI=1S/C19H23N3O.ClH/c1-21(2)13-8-14-23-19-17-11-6-7-12-18(17)22(20-19)15-16-9-4-3-5-10-16;/h3-7,9-12H,8,13-15H2,1-2H3;1H | [Contact allergens]
It is a nonsteroidal anti-inflammatory drug used both
topically and systemically. It has been reported as a
sensitizer and a photosensitizer. | [InChIKey]
HNNIWKQLJSNAEQ-UHFFFAOYSA-N | [SMILES]
C12C=CC=CC=1C(=NN2CC1C=CC=CC=1)OCCCN(C)C.Cl | [CAS DataBase Reference]
132-69-4(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
A nonsteroidal anti-inflammatory drug with local anaesthetic, analgesic and antipyretic properties. | [Uses]
A nonsteroidal anti-inflammatory with local anesthetic properties. | [Uses]
anticholinergic | [Description]
Benzydamine hydrochloride is a non-steroidal antiinflammatory
drug used both topically and systemically.
It has been reported as a sensitizer and a
photosensitizer and caused occupational contact dermatitis
in a nurse. | [Originator]
Tantum,Angelini | [Definition]
ChEBI:Benzydamine hydrochloride is a member of indazoles. | [Manufacturing Process]
To a solution of 175 g of anthranilic acid methyl ester in 2 L of water and 120
ml of concentrated hydrochloric acid at 25°C was added concentrated solution
of 80 g sodium nitrite. The product was dissolved in solution of 500 g NaOH in
1.5 L of water. To this solution under nitrogen was added 400 g of sodium
bisulfite. The mixture was stirred for 6 hours at 75°C under nitrogen. The
obtained solid product was dissolved in water and then to the solution was
added 750 ml glacial acetic acid. The yield of 1-benzyl-3-(3-(dimethylamino)
propoxy)-1H-indazole 70%, M.P. 154-156°C.
In practice it is usually used as monohydrochloride salt. | [Brand name]
Tantum (Angelini Francesco, Italy). | [Therapeutic Function]
Analgesic, Antiinflammatory, Antipyretic | [Side effects]
The major side effects of benzydamine hydrochloride are oral numbness (reported prevalence: 10 percent), and oral burning/stinging (reported prevalence: 8 percent). Oral discomfort appears to be more of a problem in patients with extensive ulceration/infammation. The oral discomfort can sometimes be improved by diluting the benzydamine hydrochloride with an equal volume of water.It is thought that benzydamine hydrochloride does not precipitate peptic ulceration. | [storage]
Store at -20°C |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36:Irritating to the eyes. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
NK7875000
| [HS Code ]
2933.99.8290 | [Safety Profile]
Poison by
intraperitoneal, subcutaneous, and
intravenous routes. Moderately toxic by
ingestion. An experimental teratogen. Other
experimental animal reproductive effects.
An eye irritant. A nonsteroidal antiinflammatory
analgesic. When heated to
decomposition it emits very toxic fumes of
HCl and NOx. | [Toxicity]
LD50 in mice, rats (mg/kg): 110, 100 i.p.; 515, 1050 orally (Silvestrini) |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|