ChemicalBook--->CAS DataBase List--->132-69-4

132-69-4

132-69-4 Structure

132-69-4 Structure
IdentificationMore
[Name]

Benzidamine hydrochloride
[CAS]

132-69-4
[Synonyms]

1-BENZYL-3-[3-(DIMETHYLAMINO)-PROPOXY]-1H-INDAZOLE HYDROCHLORIDE
BENZYDAMINE HCL
BENZYDAMINE HYDROCHLORIDE
LABOTEST-BB LT00771795
1-benzyl-3-(3-(dimethylamino)propoxy)-1h-indazolmonohydrochloride
1-benzyl-3-gamma-dimethylaminopropoxy-1h-indazolehydrochloride
af864
benalgin
benzidaminehydrochloride
benzindaminehydrochloride
benzyrin
difflam
dorinamin
enzamin
epirotin
imotryl
indolin
n,n-dimethyl-3-((1-(phenylmethyl)-1h-indazol-3-yl)oxy)-1-propanaminhydro
ririlim
riripen
[EINECS(EC#)]

205-076-0
[Molecular Formula]

C14H12ClNO2
[MDL Number]

MFCD00078957
[Molecular Weight]

261.7
[MOL File]

132-69-4.mol
Chemical PropertiesBack Directory
[Melting point ]

147-153°C
[storage temp. ]

2-8°C
[solubility ]

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
[form ]

neat
[color ]

White to Off-White
[Water Solubility ]

Soluble in water, ethanol, chloroform, n-butanol or DMSO /n
[Merck ]

14,1122
[Contact allergens]

It is a nonsteroidal anti-inflammatory drug used both topically and systemically. It has been reported as a sensitizer and a photosensitizer.
[InChIKey]

HNNIWKQLJSNAEQ-UHFFFAOYSA-N
[CAS DataBase Reference]

132-69-4(CAS DataBase Reference)
Hazard InformationBack Directory
[Chemical Properties]

Off-White Solid
[Uses]

A nonsteroidal anti-inflammatory drug with local anaesthetic, analgesic and antipyretic properties.
[Uses]

A nonsteroidal anti-inflammatory with local anesthetic properties.
[Uses]

anticholinergic
[Description]

Benzydamine hydrochloride is a non-steroidal antiinflammatory drug used both topically and systemically. It has been reported as a sensitizer and a photosensitizer and caused occupational contact dermatitis in a nurse.
[Originator]

Tantum,Angelini
[Definition]

ChEBI:Benzydamine hydrochloride is a member of indazoles.
[Manufacturing Process]

To a solution of 175 g of anthranilic acid methyl ester in 2 L of water and 120 ml of concentrated hydrochloric acid at 25°C was added concentrated solution of 80 g sodium nitrite. The product was dissolved in solution of 500 g NaOH in 1.5 L of water. To this solution under nitrogen was added 400 g of sodium bisulfite. The mixture was stirred for 6 hours at 75°C under nitrogen. The obtained solid product was dissolved in water and then to the solution was added 750 ml glacial acetic acid. The yield of 1-benzyl-3-(3-(dimethylamino) propoxy)-1H-indazole 70%, M.P. 154-156°C.
In practice it is usually used as monohydrochloride salt.
[Brand name]

Tantum (Angelini Francesco, Italy).
[Therapeutic Function]

Analgesic, Antiinflammatory, Antipyretic
[Side effects]

The major side effects of benzydamine hydrochloride are oral numbness (reported prevalence: 10 percent), and oral burning/stinging (reported prevalence: 8 percent). Oral discomfort appears to be more of a problem in patients with extensive ulceration/infammation. The oral discomfort can sometimes be improved by diluting the benzydamine hydrochloride with an equal volume of water.It is thought that benzydamine hydrochloride does not precipitate peptic ulceration.
[storage]

Store at -20°C
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36:Irritating to the eyes.
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
[WGK Germany ]

3
[RTECS ]

NK7875000
[HS Code ]

2933.99.8290
[Safety Profile]

Poison by intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion. An experimental teratogen. Other experimental animal reproductive effects. An eye irritant. A nonsteroidal antiinflammatory analgesic. When heated to decomposition it emits very toxic fumes of HCl and NOx.
[Toxicity]

LD50 in mice, rats (mg/kg): 110, 100 i.p.; 515, 1050 orally (Silvestrini)
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Water-->Sulfur dioxide-->Anthranilic acid-->2-Hydrazinobenzoic acid hydrochloride-->6,7,8-Trifluoro-1,4-dihydrogen-4-oxo-quinoline-3-carboxylate ethyl ester-->Benzydamine-->Sodium hydroxide-->Hydrochloric acid-->Sodium nitrite-->Methyl anthranilate-->1-benzyl-1,2-dihydro-3H-indazol-3-one, sodium salt-->Carbon-->3-Chloro-1-(N,N-dimethyl)propylamine
Spectrum DetailBack Directory
[Spectrum Detail]

Benzydamine hydrochloride(132-69-4)1HNMR
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

132-69-4(sigmaaldrich)
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