| Identification | Back Directory | [Name]
I2906 | [CAS]
331963-29-2 | [Synonyms]
I2906
I-2906
(I 2906
1-Ethyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinecarboxylic acid 2-(1-oxotridecyl)hydrazide
3-Quinolinecarboxylic acid, 1-ethyl-1,2-dihydro-4-hydroxy-2-oxo-, 2-(1-oxotridecyl)hydrazide | [Molecular Formula]
C25H37N3O4 | [MDL Number]
MFCD01128075 | [MOL File]
331963-29-2.mol | [Molecular Weight]
443.58 |
| Chemical Properties | Back Directory | [Boiling point ]
623.9±55.0 °C(Predicted) | [density ]
1.132±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Powder | [pka]
4.50±1.00(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
I2906 showed antimycobacterial and cytotoxic activity against mycobacterium tuberculosis.
IC50 Value:
Target: Antibacterial
Under in vitro conditions, I2906 showed excellent antimycobacterial activities and low cytotoxicity. In a murine model infected with M. tuberculosis H37Rv, the reductions on bacterial loads of both lungs and spleen were statistically significant (p < 0.05) between I2906-treated mice and untreated controls after 4 weeks. Further, the colony-forming unit counts in the lungs were dramatically lower (p < 0.05) than that of isoniazid-treated mice by the addition of I2906 after 8 weeks. Moreover, survival rate was increased by I2906 treatment. For multidrug-resistant strain infection, bacterial counts were reduced significantly in the lungs and spleen due to I2906 treatment in comparison with data from untreated controls (p < 0.05). | [References]
[1] Lu, Jingning; Yue, Jun; Wu, Jing et al. In vitro and in vivo Activities of a New Lead Compound I2906 against Mycobacterium tuberculosis. Pharmacology (2010), 85(6), 365-371. DOI:10.1159/000299795 |
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Musechem
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