| Identification | Back Directory | [Name]
C 87 | [CAS]
332420-90-3 | [Synonyms]
C 87
C87; C-87
TNFalpha-IN-C87
TNF Receptor,inhibit,Tumor Necrosis Factor Receptor,C 87,C87,Inhibitor,C-87,TNFR
3-Phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione 4-[2-(4-chloro-3-nitrophenyl)hydrazone]
1H-Pyrazole-4,5-dione, 3-phenyl-1-(4-phenyl-2-thiazolyl)-, 4-[2-(4-chloro-3-nitrophenyl)hydrazone] | [Molecular Formula]
C24H15ClN6O3S | [MOL File]
332420-90-3.mol | [Molecular Weight]
502.93 |
| Chemical Properties | Back Directory | [Boiling point ]
667.5±65.0 °C(Predicted) | [density ]
1.51±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 9.33 mg/mL (18.55 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
5.95±0.40(Predicted) | [color ]
Yellow to orange |
| Hazard Information | Back Directory | [Uses]
3-Phenyl-1-(4-phenyl-2-thiazolyl)-4-[(4-chloro-3-nitrophenyl)hydrazone]-1H-pyrazole-4,5-dione is a TNF alpha inhibitor. It also weakens inflammation and increases survival in a mouse hepatitis model. | [Biological Activity]
Cell permeable: yes''Primary Target
TNFα''Reversible: yes''Target Ki: 110 nM for hTNF&alpha | [in vivo]
C 87 (C87) attenuates TNFα-induced inflammation, thereby markedly reducing injuries to the liver and improving animal survival. C 87 injection delays the incidence of death and increases the survival rate by two folds compared with the vehicle control. The level of alanine transaminase and aspartate transaminase is consistently reduced in mice with C 87 treatment[1]. | [storage]
Store at +4°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|