| Identification | More | [Name]
2-Hydroxy-5-trifluoromethylpyridine | [CAS]
33252-63-0 | [Synonyms]
2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE
5-TRIFLUOROMETHYL-2-(1H)-PYRIDINONE
5-(TRIFLUOROMETHYL)-2(1H)-PYRIDONE
5-(TRIFLUOROMETHYL)-2-PYRIDINOL
BUTTPARK 24\01-67
5-TRIFLOROMETHYL-2-(1H)-PYRIDINONE
5-(Trifluoromethyl)pyridin-2-one
5-Trifluoromethyl-pyridin-2-ol
2-Hydroxy-5-(trifluoromethyl)pyridine 97%
2-Hydroxy-5-(trifluoromethyl)pyridine97%
5-Trifluoromethyl-2-hydroxypyridine
5-(Trifluoromethyl)pyridin-2-ol, 5-(Trifluoromethyl)pyridin-2(1H)-one
5-(Trifluoromethyl)-2-pyridinone
5-(Trifluoromethyl)-2-pyridone
2(1H)-Pyridinone, 5-(trifluoromethyl)- | [EINECS(EC#)]
627-625-7 | [Molecular Formula]
C6H4F3NO | [MDL Number]
MFCD00042315 | [Molecular Weight]
163.1 | [MOL File]
33252-63-0.mol |
| Chemical Properties | Back Directory | [Appearance]
Yellow to brown powder | [Melting point ]
145-149 °C (lit.) | [Boiling point ]
221.2±40.0 °C(Predicted) | [density ]
1.398±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
DMSO (Soluble), Ethanol (Sparingly), Methanol (Sightly) | [form ]
Crystalline Powder | [pka]
9.55±0.10(Predicted) | [color ]
White to beige | [InChI]
InChI=1S/C6H4F3NO/c7-6(8,9)4-1-2-5(11)10-3-4/h1-3H,(H,10,11) | [InChIKey]
BYRJSCNPUHYZQE-UHFFFAOYSA-N | [SMILES]
C1(=O)NC=C(C(F)(F)F)C=C1 | [CAS DataBase Reference]
33252-63-0(CAS DataBase Reference) | [EPA Substance Registry System]
2(1H)-Pyridinone, 5-(trifluoromethyl)- (33252-63-0) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R65:Harmful: May cause lung damage if swallowed.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R20/21:Harmful by inhalation and in contact with skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29339900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow to brown powder | [Uses]
2-Hydroxy-5-(trifluoromethyl)pyridine (cas# 33252-63-0) is a compound useful in organic synthesis. | [General Description]
2-Hydroxy-5-(trifluoromethyl)pyridine, a pyridine derivative, is a heterocyclic building block. They have useful applications in catalysis, drug design, molecular recognition, and natural product synthesis. | [Synthesis]
General procedure for the synthesis of 2-hydroxy-5-trifluoromethylpyridine from 6-hydroxynicotinic acid: 6-hydroxynicotinic acid (18.2 g, 0.13 mol), anhydrous hydrofluoric acid (2.6 mL, 0.13 mol, ≥95 wt%) and sulfur tetrafluoride (42.1 g, 0.39 mol) were added to a stainless steel pressure tank. The mixture was heated to 100 °C and reacted at 0.15 MPa pressure for 12 hours. The gaseous product generated during the reaction was treated by an exhaust gas absorption unit. Upon completion of the reaction, the remaining product was transferred to a polytetrafluoroethylene vessel and heated to 40°C to remove residual hydrogen fluoride. Subsequently, the product was dissolved in 150 mL of water and the pH was adjusted to 6.8-7.2 with saturated sodium carbonate solution. the aqueous phase was extracted with chloroform, and the organic phases were combined and dried. After filtration and drying, 2-hydroxy-5-trifluoromethylpyridine (15.3 g, 0.094 mol) was obtained in 72% yield. | [References]
[1] Patent: CN102875453, 2016, B. Location in patent: Paragraph 0023 |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
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| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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