| Hazard Information | Back Directory | [Uses]
ODN 2336 is a A-Class CpG ODN (oligodeoxynucleotides), is a potent TLR9 agonist. ODN 2336 induces the production of IFN-α. ODN 2336 up-regulates the expression of IP-10 mRNA and IL-18 mRNA. ODN 2336 can be used as adjuvant of vaccines[1][2][3]. | [References]
[1] urk M, et al. C-Class CpG ODN: sequence requirements and characterization of immunostimulatory activities on mRNA level. Immunobiology. 2004;209(1-2):141-54. DOI:10.1016/j.imbio.2004.02.006
[2] old MC, et al. Purified neonatal plasmacytoid dendritic cells overcome intrinsic maturation defect with TLR agonist stimulation. Pediatr Res. 2006 Jul;60(1):34-7. DOI:10.1203/01.pdr.0000220352.13547.f4
[3] Hilbert T, et al. Beta2-adrenoceptor stimulation suppresses TLR9-dependent IFNA1 secretion in human peripheral blood mononuclear cells. PLoS One. 2013 May 28;8(5):e65024. DOI:10.1371/journal.pone.0065024 |
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Asymchem Labs.
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17347534561 |
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https://www.asymchem.com.cn/ |
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