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333357-56-5

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333357-56-5 Structure

333357-56-5 Structure
IdentificationBack Directory
[Name]

Benzamide, N-(4-iodophenyl)-4-(4-morpholinylmethyl)-
[CAS]

333357-56-5
[Synonyms]

WAY-299838
HIF-1 inhibitor-4
N-(4-Iodophenyl)-4-(morpholinomethyl)benzamide
Benzamide, N-(4-iodophenyl)-4-(4-morpholinylmethyl)-
[Molecular Formula]

C18H19IN2O2
[MOL File]

333357-56-5.mol
[Molecular Weight]

422.26
Chemical PropertiesBack Directory
[Boiling point ]

435.4±45.0 °C(Predicted)
[density ]

1.576±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

12.90±0.70(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

HIF-1 inhibitor-4 is a HIF-1 inhibitor (IC50: 560 nM). HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA level[1].
[References]

[1] Nagao S, et al. Synthesis and structure-activity relationships of novel, potent, orally active hypoxia-inducible factor-1 inhibitors. Bioorg Med Chem. 2014 Oct 1;22(19):5513-29. DOI:10.1016/j.bmc.2014.07.020
Spectrum DetailBack Directory
[Spectrum Detail]

Benzamide, N-(4-iodophenyl)-4-(4-morpholinylmethyl)-(333357-56-5)1HNMR
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