| Identification | Back Directory | [Name]
Ethanone, 1-(4-bromophenyl)-2-[[5-(4-pyridinyl)-1,3,4-oxadiazol-2-yl]thio]- | [CAS]
491839-65-7 | [Synonyms]
FAK-IN-10
WAY-320461
Ethanone, 1-(4-bromophenyl)-2-[[5-(4-pyridinyl)-1,3,4-oxadiazol-2-yl]thio]- | [Molecular Formula]
C15H10BrN3O2S | [MOL File]
491839-65-7.mol | [Molecular Weight]
376.23 |
| Chemical Properties | Back Directory | [Boiling point ]
570.1±60.0 °C(Predicted) | [density ]
1.65±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
0.93±0.10(Predicted) | [color ]
Light yellow to khaki |
| Hazard Information | Back Directory | [Uses]
FAK-IN-10 is an inhibitor of FAK with an IC50 of 76.3 μM. FAK-IN-10 exhibits antitumor activity against MCF-7 and A431 cell lines with IC50s of 4.23 and 0.78 μM,respectively[1]. | [References]
[1] Zhang LR, et al. Synthesis, biological evaluation and molecular docking studies of novel 2-(1,3,4-oxadiazol-2-ylthio)-1-phenylethanone derivatives. Bioorg Med Chem. 2012 Jun 1;20(11):3615-21. DOI:10.1016/j.bmc.2012.03.061 |
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