| Chemical Properties | Back Directory | [Boiling point ]
319.9±52.0 °C(Predicted) | [density ]
1.77±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml | [form ]
A crystalline solid | [pka]
4.42±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
CAY10761 is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1. It also inhibits mushroom tyrosinase and urease from jack bean, P. mirabilis, and B. pasteurii. | [Uses]
5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione is a weak inhibitor for snake venom and human recombinant phosphodiesterase 1 with IC50 of 429 and 467 μM. 5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione inhibits mushroom tyrosinase weakly, with Ki of 1.9 μM[1][2]. | [References]
[1] Khan KM, et al., 1,3,4-Oxadiazole-2(3H)-thione and its analogues: a new class of non-competitive nucleotide pyrophosphatases/phosphodiesterases 1 inhibitors. Bioorg Med Chem. 2009 Nov 15;17(22):7816-22. DOI:10.1016/j.bmc.2009.09.011
[2] Ghani U, et al., New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site. Bioorg Med Chem. 2010 Jun 1;18(11):4042-8. DOI:10.1016/j.bmc.2010.04.021 |
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