| Identification | More | [Name]
SPERMIDINE TRIHYDROCHLORIDE | [CAS]
334-50-9 | [Synonyms]
1,8-DIAMINO-4-AZAOCTANE TRIHYDROCHLORIDE
N-[3-AMINOPROPYL]-1,4-BUTANEDIAMINE 3 H CL
N-(3-AMINOPROPYL)-1 4-BUTANEDIAMINE HYDROCHLORIDE
N-(3-AMINOPROPYL)-1,4-BUTANEDIAMINE TRIHYDROCHLORIDE
N-(3-AMINOPROPYL)-1,4-DIAMINOBUTANE 3HCL
N-(3-AMINOPROPYL)-1,4-DIAMINO-BUTANE TRIHYDROCHLORIDE
SPERMIDINE 3HCL
SPERMIDINE HYDROCHLORIDE
SPERMIDINE TRIHYDROCHLORIDE
1,4-Butanediamine,N-(3-aminopropyl)-,trihydrochloride
4-butanediamine,n-(3-aminopropyl)-trihydrochloride
4-azoniaoctamethylenediammonium trichloride
SPERMIDINE HCl
SPERMIDINE TRIHYDROCHLORIDE N-(3-AMINOPR OPYL)-1,4
Spermidine trihydrochloride, 99+%
Spermidine·3hydrochloride | [EINECS(EC#)]
206-379-0 | [Molecular Formula]
C7H22Cl3N3 | [MDL Number]
MFCD00012918 | [Molecular Weight]
254.63 | [MOL File]
334-50-9.mol |
| Chemical Properties | Back Directory | [Appearance]
white crystalline powder | [Melting point ]
257-259 °C(lit.)
| [storage temp. ]
2-8°C
| [solubility ]
H2O: 1 M at 20 °C, clear, colorless
| [form ]
Crystalline Powder | [color ]
White | [PH]
3.0-6.0 (25℃, 1M in H2O) | [biological source]
microbial
synthetic | [Water Solubility ]
Soluble in water | [λmax]
λ: 260 nm Amax: 0.2
λ: 280 nm Amax: 0.1 | [BRN ]
3552356 | [Cosmetics Ingredients Functions]
HAIR CONDITIONING | [InChI]
InChI=1S/C7H19N3.3ClH/c8-4-1-2-6-10-7-3-5-9;;;/h10H,1-9H2;3*1H | [InChIKey]
LCNBIHVSOPXFMR-UHFFFAOYSA-N | [SMILES]
C(CCCN)NCCCN.Cl.Cl.Cl | [CAS DataBase Reference]
334-50-9(CAS DataBase Reference) | [EPA Substance Registry System]
1,4-Butanediamine, N-(3-aminopropyl)-, trihydrochloride (334-50-9) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319 | [Precautionary statements ]
P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3 | [RTECS ]
EJ7023000 | [F ]
3-10 | [TSCA ]
Yes | [HS Code ]
29212900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2 |
| Hazard Information | Back Directory | [Description]
Spermidine trihydrochloride(334-50-9) is a polyamine that inhibits neuronal nitric oxide synthase (nNOS) and binds and precipitates DNA. It may be used to purify DNA binding proteins. Additionally, spermidine stimulates T4 polynucleotide kinase activity. It is involved in growth, development, and the stress response in plants.
| [Chemical Properties]
white crystalline powder | [Chemical Reactivity]
Spermidine hydrochloride is a white crystal at normal temperature and pressure. It is the hydrochloride form of spermidine.When it is used, it is often reacted with alkali to release a triamine structure. | [Uses]
Spermidine trihydrochloride has been used in fourier transform infrared spectroscopy (FTIR)characterization and in zeta-potential measurements. | [Application]
Polyamine that plays an important role in the regulation of cellular proliferation and differentiation. Inhibits neuronal nitric oxide synthase. Spermidine trihydrochloride has been used in fourier transform infrared spectroscopy (FTIR)characterization and in zeta-potential measurements. | [Definition]
Spermidine trihydrochloride powder is the trihydrochloride form of spermidine. Spermidine base is in liquid form, while Spermidine trihydrochloride is in powder form. Spermidine trihydrochloride is a more stable form because spermidine is very air-sensitive. Spermidine trihydrochloride powder benefits are the same as Spermidine benefits.
| [benefits]
Spermidine trihydrochloride has been extensively studied for its potential health benefits, including its ability to modulate autophagy, enhance cardiovascular health, protect against neurodegenerative diseases, and exhibit antioxidant activity. Studies have shown that it can enhance cardiovascular health by promoting blood vessel relaxation, reducing oxidative stress, and improving mitochondrial function. It has also been suggested to have neuroprotective effects and may contribute to cognitive health and brain function. It has shown promising results in preclinical studies, demonstrating its ability to protect neurons, reduce inflammation, and enhance cellular resilience.
| [Biological Functions]
Spermidine inhibits NOS1 (nNOS). Spermidine binds and precipitates DNA and may be used for purification of DNA binding proteins. Spermidine activates PNK (polynucleotide kinase T4). Spermidine binds to and activates NMDA and has been shown to potentiate NMDA-induced currents in a concentration-dependent manner. | [General Description]
Spermidine trihydrochloride(334-50-9) is the hydrochloric acid neutralized salt of spermidine. Spermidine is a polyamine and a trivalent organic cation. It is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy. External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies and mice. Spermidine trihydrochloride is a more stable form because spermidine is very air sensitive.
| [Biological Activity]
Binds to the polyamine modulatory site of the NMDA receptor and has been described as an agonist based on its ability to enhance the binding of [ 3 H]-MK801. | [Biochem/physiol Actions]
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity. | [storage]
+4°C (desiccate) | [Purification Methods]
Recrystallise the salt from dry 3% HCl in ethanol and adding dry Et2O if necessary. Filter it off rapidly and dry it in a vacuum desiccator. Alternatively centrifuge the crystals off, wash them with dry Et2O and dry them in a vacuum. [Beilstein 4 IV 1300.] |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
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