| Identification | Back Directory | [Name]
2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS | [CAS]
33400-49-6 | [Synonyms]
2-Amino-6-(4-fL
N2-(4-Fluorobenzyl)
Flupirtine impurity B
amino)-3-nitropyridine
-5-nitropyridine-2,6-diamine
FlupirtinemaleateintermediateⅡ
N2-(4-fluorobenzyl)-5-nitropyridine-2,6-diaMine
2-Amino-3-nitro-6-(4-fluorobenzylamino)pyridine
2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE
2-Amino-6-[(4-fluorobenzyl)-amino]-3-nitropyridine
N6-[(4-fluorophenyl)methyl]-3-nitropyridine-2,6-diamine
N6-[(4-Fluorophenyl)Methyl]-3-nitro-2,6-pyridinediaMine
6-[[(4-Fluorophenyl)methyl]amino]-3-nitro-2-pyridinamine
6-n-[(4-fluorophenyl)Methyl]-3-nitropyridine-2,6-diaMine
2,6-PyridinediaMine,N6-[(4-fluorophenyl)Methyl]-3-nitro-
2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS
2,6-PYRIDINEDIAMINE,N6-[(4-FLUOROPHENYL)METHYL]-3-NITRO- (CAS NO.33400-49-6)
2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE SPECIALITY CHEMICALS ISO 9001：2015 REACH | [EINECS(EC#)]
251-498-3 | [Molecular Formula]
C12H11FN4O2 | [MDL Number]
MFCD08282317 | [MOL File]
33400-49-6.mol | [Molecular Weight]
262.24 |
| Chemical Properties | Back Directory | [Melting point ]
178-180°C | [Boiling point ]
464.5±45.0 °C(Predicted) | [density ]
1.447±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
1.52±0.50(Predicted) | [color ]
Yellow | [InChI]
1S/C12H11FN4O2/c13-9-3-1-8(2-4-9)7-15-11-6-5-10(17(18)19)12(14)16-11/h1-6H,7H2,(H3,14,15,16) | [InChIKey]
ZVCIIRBNNSUNCH-UHFFFAOYSA-N | [SMILES]
NC1=NC(NCC2=CC=C(F)C=C2)=CC=C1[N+]([O-])=O |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Solid | [Uses]
Intermediate in the preparation of Flupirtine metabolites. | [Synthesis]
To a reaction flask was added 200 mL of methanol, 52.08 g of 2-amino-3-nitro-6-chloropyridine (compound 1), 37.54 g of p-fluorobenzylamine and 50.0 mL of triethylamine. The reaction mixture was heated to 80 °C and kept for 10 hours. After completion of the reaction, 10 times the volume of water was added to the reaction solution and a solid was precipitated, which was filtered and dried to give 76.47 g of 2-amino-3-nitro-6-(4-fluorobenzylamino)pyridine (Compound 3) in 97.2% yield and 99.62% purity (as determined by HPLC). | [References]
[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 23, p. 9739 - 9756
[2] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2012, vol. 67, # 12, p. 1297 - 1304
[3] Patent: CN105541705, 2016, A. Location in patent: Paragraph 0013; 0027; 0028
[4] Patent: WO2012/4391, 2012, A1. Location in patent: Page/Page column 39
[5] Patent: CN104086481, 2016, B. Location in patent: Paragraph 0033 - 0037 |
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