| Identification | More | [Name]
1-BROMO-2-BUTYNE | [CAS]
3355-28-0 | [Synonyms]
1-BROMO-2-BUTYNE
2-BUTYNYL BROMIDE
1-BROMO-2-BUTYNE 98% | [EINECS(EC#)]
608-891-3 | [Molecular Formula]
C4H5Br | [MDL Number]
MFCD00190233 | [Molecular Weight]
132.99 | [MOL File]
3355-28-0.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear pale yellow-greenish liquid | [Boiling point ]
40-41 °C/20 mmHg (lit.) | [density ]
1.519 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.508(lit.)
| [Fp ]
97 °F
| [storage temp. ]
Flammables area | [solubility ]
Miscible with acetonitrile. | [form ]
Liquid | [color ]
Clear pale yellow-greenish | [Specific Gravity]
1.519 | [BRN ]
605306 | [InChI]
InChI=1S/C4H5Br/c1-2-3-4-5/h4H2,1H3 | [InChIKey]
LNNXOEHOXSYWLD-UHFFFAOYSA-N | [SMILES]
C(Br)C#CC | [CAS DataBase Reference]
3355-28-0(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Clear pale yellow-greenish liquid | [Uses]
1-Bromo-2-butyne is used in the preparation of six to eight annulated ring compounds in reaction with indoles and pseudopterane (+/-)-Kallolide B, which is a marine natural product. Further, it acts as a precursor in the preparation of axially chiral teranyl compounds, alkylation of L-tryptophan methyl ester, 4-butynyloxybenzene sulfonyl chloride and mono-propargylated diene derivative. In addition to this, it is also used in the synthesis of isopropylbut-2-ynylamine, allenylcyclobutanol derivatives, allyl-[4-(but-2-ynyloxy)phenyl]sulfane, allenylindium and axially chiral teranyl compounds. | [Preparation]
1-bromo-2-butyne is obtained by reacting 2-butyn-1-ol and organic solvent, pyridine.First react bromoethane with metal magnesium in THF to prepare Grignard reagent, then add paraformaldehyde to Grignard reagent for Grignard reaction, separate and recover after Grignard reaction 2-butyn-1-ol, then mix 2-butyn-1-ol with organic solvent and pyridine, add phosphorus tribromide dropwise for bromination reaction, separate and recover the product after bromination reaction. | [General Description]
1-Bromo-2-butyne is a propargyl bromide derivative. It is one of the constitutional isomer of bromo butyne. Its Br-loss threshold photoionization breakdown diagram has been analyzed to derive dissociative photoionization thresholds to C4H5+ production. It participates in the preparation of linagliptin. |
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