33763-20-1

53715-64-3

33763-20-1

General method: 2N aqueous sodium hydroxide solution was slowly added to a methanol solution containing ethyl 4-methyl-2-phenyl-1,3-thiazole-5-carboxylate (1 eq.) at room temperature. The reaction mixture was stirred continuously for 4 hours at room temperature. After completion of the reaction, the methanol solvent was removed by rotary evaporator. Subsequently, the pH of the reaction mixture was adjusted to 5-6 with 1N hydrochloric acid solution.The precipitated white solid was collected by filtration and processed by drying to finally give 4-methyl-2-phenylthiazole-5-carboxylic acid (1a-i).